Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum

  • Planta Med. 2017 Jan;83(1-02):143-150. doi: 10.1055/s-0042-109778.
Yan-Ni Shi  1 ,  Fang-Fang Liu  1 ,  Melissa R Jacob  2 ,  Xing-Cong Li  2 ,  Hong-Tao Zhu  1 ,  Dong Wang  1 ,  Rong-Rong Cheng  1 ,  Chong-Ren Yang  1 ,  Min Xu  1 ,  Ying-Jun Zhang  1
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • 2. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, United States.
PMID: 27405106 DOI: 10.1055/s-0042-109778
Abstract

Sixty-three amide Alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3- hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their Antifungal and Antibacterial activities. Ten amides (6-15) showed Antifungal activity against Cryptococcus neoformans ATCC 90 113 with IC50 values in the range between 4.7 and 20.0 µg/mL.

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