country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DECR1 - 2,4-dienoyl-CoA reductase 1 Gene

Also Known as DECR; NADPH; SDR18C1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1666

About DECR1

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:90,001,477-90,053,633 (from NCBI)

This gene has 19 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 86.6), fat (RPKM 60.8) and 25 other tissues.

Summary

This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]

DECR1 Products (2)

mRNA	Protein	Name
NM_001330575.2	NP_001317504.1	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 2
NM_001359.2	NP_001350.1	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2,4-dienoyl-CoA reductase (NADPH) activity	IDA IDA: Inferred from direct assay	15531764	GOA
enables NADPH binding	IDA IDA: Inferred from direct assay	15531764	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15531764	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	15531764	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of catalytic complex	IDA IDA: Inferred from direct assay	15531764	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DECR1 Protein Structure

adh_short_C2

0
100
200
300
335 a.a.

Protein Preferred Names	Protein Names
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial	2,4-dienoyl-CoA reductase 1, mitochondrial

Related Diseases

Diseases	Alias
2,4-Dienoyl-Coa Reductase Deficiency	Progressive Encephalopathy With Leukodystrophy Due To Decr Deficiency DECRD 2,4-Alpha Dienoyl-Coa Reductase Deficiency Dienoyl-Coa Reductase Deficiency Decr Deficiency With Hyperlysinemia
Hyperlysinemia, Type I	Hyperlysinemia Lysine Intolerance Alpha-Aminoadipic Semialdehyde Synthase Deficiency Lysine:Alpha-Ketoglutarate Reductase Deficiency L-Lysine:Nad-Oxido-Reductase Deficiency Lysine Alpha-Ketoglutarate Reductase Deficiency Alpha-Aminoadipic Semialdehyde Deficiency Disease Lysine Alpha-Ketoglutarate Reductase Deficiency Disease Saccharopinuria Hyperlysinemia Type I Hyperlysinemias L-Lysine Nad-Oxido-Reductase Deficiency Familial Hyperlysinemia Saccharopine Dehydrogenase Deficiency Disease Hyperlysinemia, 1 HYPLYS1 Saccharopine Dehydrogenase Deficiency
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia	Kallmann Syndrome 2 Kal2 HH2 Hypogonadism, Hypogonadotropic, Type 2 With/Without Anosmia
Mitochondrial Complex I Deficiency, Nuclear Type 20	Acyl-Coa Dehydrogenase 9 Deficiency Acad9 Deficiency MC1DN20 Mitochondrial Complex I Deficiency Due To Acad9 Deficiency Nuclear Type Mitochondrial Complex I Deficiency 20 Acyl-Coa Dehydrogenase Family, Member 9, Deficiency Of Mitochondrial Complex 1 Deficiency Due To Acad9 Deficiency Deficiency Of Acyl-Coa Dehydrogenase Family Member 9 Acyl-Coa Dehydrogenase Family, Member 9, Deficiency
Multiple Acyl-Coa Dehydrogenase Deficiency	MADD Ethylmalonic-Adipicaciduria Ema Glutaric Acidemia Iia Glutaric Acidemia Iib Ga Ii Glutaric Acidemia Iic Glutaric Acidemia Type 2 Glutaric Acidemia Ii Glutaric Aciduria Ii Electron Transfer Flavoprotein Deficiency Glutaric Aciduria Type 2 Mad Deficiency Glutaric Acidemia Type Ii Glutaric Aciduria 2 Etfa Deficiency Etfb Deficiency Etfdh Deficiency Multiple Acyl Coenzyme A Dehydrogenase Deficiency Ga2 Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency Electron Transfer Flavoprotein Dehydrogenase Deficiency Ga 2 Glutaric Acidemia 2 Glutaric Acidemia, Type 2 Glutaric Aciduria, Type 2 Mad Multiple Fad Dehydrogenase Deficiency Ethylmalonic Adipic Aciduria Glutaricaciduria Ii Glutaric Aciduria 2a GA2A Gaiia Glutaricaciduria Iia Glutaric Aciduria 2b GA2B Gaiib Glutaricaciduria Iib Glutaric Aciduria 2c GA2C Gaiic Glutaricaciduria Iic Glutaricaciduria, Type Iia Glutaric Acidemia Type 2a Glutaric Acidemia Type 2c Glutaric Aciduria Iia Glutaric Aciduria Iib Glutaric Aciduria Iic
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03667	DECR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18996	Decr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25485	Decr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DECR1	RGD	RGD:70999
Bos taurus	DECR1	VGNC	VGNC:27982
Canis familiaris	DECR1	VGNC	VGNC:39871
Felis catus	DECR1	VGNC	VGNC:81646
Mus musculus	DECR1	MGD	MGI:1914710
Macaca mulatta	DECR1	VGNC	VGNC:81386
Others	DECR1	NCBI