TRAM2 - translocation associated membrane protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9697

About TRAM2

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,497,408-52,577,060 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 2 paralogues. Broad expression in placenta (RPKM 12.1), testis (RPKM 6.9) and 23 other tissues.

Summary

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]

TRAM2 Products (1)

mRNA Protein Name
NM_012288.4 NP_036420.1 translocating chain-associated membrane protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14749390 GOA
Biological Process GO Annotation Evidence References Source
involved in collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
14749390 GOA
involved in protein insertion into ER membrane IDA
IDA: Inferred from direct assay
27499293 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAM2 Protein Structure

TRAM1

TRAM1: TRAM1-like protein (48 - 111)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (113 - 311)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

translocating chain-associated membrane protein 2

  • TRAM-like protein

TRAM2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811350 TRAM2 Antibody WB, IHC-P Human

Related Diseases

Diseases Alias
Epilepsy, Myoclonic Juvenile

  • Juvenile Myoclonic Epilepsy

  • Janz Syndrome

  • Jme

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

  • EJM

  • Myoclonic Epilepsy, Juvenile

  • Petit Mal, Impulsive

  • Myoclonic Epilepsy, Juvenile 1

  • Myoclonic Epilepsy, Juvenile, 1

  • Adolescent Myoclonic Epilepsy

  • Juvenile Myoclonus Epilepsy

  • Juvenile Myoclonic Epilepsy 1

  • EJM1

  • Petit Mal Impulsive

  • Susceptibility To Juvenile Myoclonic Epilepsy 1

  • Myoclonic Epilepsy Juvenile

  • Epilepsy, Myoclonic, Juvenile

  • Myoclonic Epilepsy Of Janz

  • Jme - [Juvenile Myoclonic Epilepsy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14982 TRAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22875 Tram2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29389 Tram2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRAM2 VGNC VGNC:54242
Rattus norvegicus TRAM2 RGD RGD:1589151
Macaca mulatta TRAM2 VGNC VGNC:83515
Felis catus TRAM2 VGNC VGNC:102540
Canis familiaris TRAM2 VGNC VGNC:49104
Mus musculus TRAM2 MGD MGI:1924817
Others TRAM2 NCBI