APH-IN-1
APH-IN-1 is an Aminoglycoside phosphotransferase (APH) inhibitor with a Kd values of 63 nM against Escherichia coli APH(3′)-Ia. APH-IN-1 binds primarily to the ATP-binding pocket of APH in an ATP-competitive manner, with binding affinity enhanced by divalent metal ions (Mg2+ and Ca2+). APH-IN-1 can be used for the research of aminoglycoside-resistant bacterial infections.
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- Formule: C60H90N14O11S2
- Masse moléculaire:1247.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
APH-IN-1 (Compound I-L3) (20 nM; 30 min) binds to purified Escherichia coli-derived APH(3′)-Ia with a Kd of 63 nM[1].
APH-IN-1 (20 nM; 30 min) exhibits enhanced binding to purified Escherichia coli-derived APH(3′)-Ia in the presence of divalent metal ions[1].
APH-IN-1 (20 nM) binds primarily to the ATP-binding pocket of purified Escherichia coli-derived APH(3′)-Ia, as shown by competitive displacement by ATP[1].
APH-IN-1 (0.1-5.00 μM; 1 h) inhibits the activity of purified Escherichia coli-derived APH(3′)-Ia in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 1247.57
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Formule C60H90N14O11S2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APH-IN-1 Related Classifications
HY-P11825 Related Classifications
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