Avarol
Avarol is a sesquiterpene hydroquinone that can be isolated from Dysidea avara sponge. Avarol has the potential for the research of ehrlich carcinoma (EC) and cervical cancer (CC-5).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 55303-98-5
- Formule: C21H30O2
- Masse moléculaire:314.46
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6 μM
Compound: 1 (Avarol)
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Cytotoxicity was measured against neoplastic cultured A-549 cells of human lung carcinoma.
Cytotoxicity was measured against neoplastic cultured A-549 cells of human lung carcinoma.
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10.1016/0960-894X(96)00326-5 |
| A549 | IC50 |
6.4 μM
Compound: Avarol
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Cytotoxic activity against cultured cells of A-549 human lung carcinoma.
Cytotoxic activity against cultured cells of A-549 human lung carcinoma.
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[PMID: 11312925] |
| CHO | IC50 |
12 μM
Compound: 1
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Inhibition of SOAT1 in CHO cell microsomal fraction using [1-14C]oleoyl-CoA as substrate measured after 5 mins by TLC based method
Inhibition of SOAT1 in CHO cell microsomal fraction using [1-14C]oleoyl-CoA as substrate measured after 5 mins by TLC based method
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[PMID: 31253530] |
| CHO | IC50 |
14.2 μM
Compound: 1
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Inhibition of African green monkey SOAT1 expressed in CHO cells using [1-14C]oleic acid incubated for 6 hrs by TLC based method
Inhibition of African green monkey SOAT1 expressed in CHO cells using [1-14C]oleic acid incubated for 6 hrs by TLC based method
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[PMID: 31253530] |
| CHO | IC50 |
14.8 μM
Compound: 1
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Inhibition of African green monkey SOAT2 expressed in CHO cells using [1-14C]oleic acid incubated for 6 hrs by TLC based method
Inhibition of African green monkey SOAT2 expressed in CHO cells using [1-14C]oleic acid incubated for 6 hrs by TLC based method
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[PMID: 31253530] |
| CHO | IC50 |
8.1 μM
Compound: 1
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Inhibition of SOAT2 in CHO cell microsomal fraction using [1-14C]oleoyl-CoA as substrate measured after 5 mins by TLC based method
Inhibition of SOAT2 in CHO cell microsomal fraction using [1-14C]oleoyl-CoA as substrate measured after 5 mins by TLC based method
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[PMID: 31253530] |
| CHO-K1 | IC50 |
>30.9 μM
Compound: 1
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Cytotoxicity against CHOK1 cells assessed as reduction in cell viability
Cytotoxicity against CHOK1 cells assessed as reduction in cell viability
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[PMID: 31253530] |
| HEK293 | IC50 |
>10 μM
Compound: Avarol
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Inhibition of TNF alpha-induced NF-kappaB (unknown origin) activation in HEK293 cells after 6 hrs by luciferase reporter gene assay
Inhibition of TNF alpha-induced NF-kappaB (unknown origin) activation in HEK293 cells after 6 hrs by luciferase reporter gene assay
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[PMID: 26863083] |
| HeLa | IC50 |
19.7 μM
Compound: 1
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Cytotoxicity against human HeLa cells assessed as decrease in total cellular protein by kenacid blue R binding method
Cytotoxicity against human HeLa cells assessed as decrease in total cellular protein by kenacid blue R binding method
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[PMID: 19995673] |
| HT-29 | IC50 |
6 μM
Compound: 1 (Avarol)
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Cytotoxicity was measured against neoplastic cultured HT-29 cells of human colon carcinoma.
Cytotoxicity was measured against neoplastic cultured HT-29 cells of human colon carcinoma.
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10.1016/0960-894X(96)00326-5 |
| HT-29 | IC50 |
6.4 μM
Compound: Avarol
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Cytotoxic activity against cultured cells of HT-29 human colon carcinoma.
Cytotoxic activity against cultured cells of HT-29 human colon carcinoma.
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[PMID: 11312925] |
| K562 | IC50 |
7.3 μM
Compound: 1
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Cytotoxicity against human K562 cells by MTT assay
Cytotoxicity against human K562 cells by MTT assay
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[PMID: 19995673] |
| NCI-H929 | IC50 |
3.32 μM
Compound: Avarol
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Cytotoxicity against human NCI-H929 cells after 48 hrs by MTS assay
Cytotoxicity against human NCI-H929 cells after 48 hrs by MTS assay
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[PMID: 26863083] |
| Neutrophil | IC50 |
3.6 μM
Compound: 1
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Inhibition of TPA-induced ROS production in human neutrophils by chemiluminescence
Inhibition of TPA-induced ROS production in human neutrophils by chemiluminescence
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[PMID: 15387642] |
| P388 | IC50 |
3.1 μM
Compound: 1 (Avarol)
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Cytotoxicity was measured against neoplastic cultured P-388 cells of murine leukemia.
Cytotoxicity was measured against neoplastic cultured P-388 cells of murine leukemia.
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10.1016/0960-894X(96)00326-5 |
| P388 | IC50 |
3.2 μM
Compound: Avarol
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Cytotoxic Activity against cultured cells of P-388 murine leukemia.
Cytotoxic Activity against cultured cells of P-388 murine leukemia.
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[PMID: 11312925] |
| PBMC | IC50 |
3 μM
Compound: 1
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Cytotoxicity against human PBMC cells by MTT assay
Cytotoxicity against human PBMC cells by MTT assay
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[PMID: 19995673] |
| PBMC | IC50 |
3.2 μM
Compound: 1
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Cytotoxicity against human phytohemagglutininin-stimulated PBMC cells assessed as growth inhibition by MTT assay
Cytotoxicity against human phytohemagglutininin-stimulated PBMC cells assessed as growth inhibition by MTT assay
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[PMID: 19995673] |
| SK-MEL-28 | IC50 |
6 μM
Compound: 1 (Avarol)
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Cytotoxicity was measured against neoplastic cultured MEL-28 cells of malign human melanoma.
Cytotoxicity was measured against neoplastic cultured MEL-28 cells of malign human melanoma.
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10.1016/0960-894X(96)00326-5 |
| SK-MEL-28 | IC50 |
6.4 μM
Compound: Avarol
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Cytotoxic activity against cultured cells of MEL-28 malign human melanoma.
Cytotoxic activity against cultured cells of MEL-28 malign human melanoma.
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[PMID: 11312925] |
Avarol (12.5, 25, 50, 100, 200 µg/mL; 72 h) shows cytotoxic for HeLa, LS174, A549, MRC-5 cells with IC50s of 10.22, 34.06, 35.27, 29.14 µg/mL, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, LS174, A549, MRC-5 cells
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Concentration:12.5, 25, 50, 100, 200 µg/mL
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Incubation Time:72 h
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Result:Exhibited the cytotoxic for HeLa, LS174, A549, MRC-5 cells with IC50s of 10.22, 34.06, 35.27, 29.14 µg/mL, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:female F1 (CBA × C57BL/6j) mice (Ehrlich carcinoma)[1]
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Dosage:50 mg/kg
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Administration:I.p.; daily for 14 days
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Result:Inhibited tumor growth with a stable inhibition (25-35%) of EC growth.
Chemical Information
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CAS No. 55303-98-5
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Appearance Solid
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Masse moléculaire 314.46
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Formule C21H30O2
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Color Light brown to brown
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SMILES
OC1=CC=C(O)C=C1C[C@]2(C)[C@@H](C)CC[C@]3(C)C(C)=CCC[C@@]23[H]
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Synonyms
(+)-Avarol
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Structure Classification
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Initial Source
Dysidea avara
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Stanojkovic TP, et al. Evaluation of In Vitro Cytotoxic Potential of Avarol towards Human Cancer Cell Lines and In Vivo Antitumor Activity in Solid Tumor Models. Molecules. 2022 Dec 19;27(24):9048. [Content Brief]
[2]. Namba T, Kodama R. Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Mar Drugs. 2015;13(4):2376-2389. [Content Brief]
[3]. Amigó M, Payá M, Braza-Boïls A, De Rosa S, Terencio MC. Avarol inhibits TNF-alpha generation and NF-kappaB activation in human cells and in animal models. Life Sci. 2008;82(5-6):256-264. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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