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Cat. No.: HY-137061

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AZ-GHS-22

AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC₅₀=0.77 nM).

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CAS No.: 1143020-91-0
Formule: C₂₇H₃₃ClN₆O₅S₂
Masse moléculaire:621.17

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

AZ-GHS-22 Chemical Structure

CAS No.: 1143020-91-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC₅₀=0.77 nM)^[1].

Voir tous les produits spécifiques à Isoform GHSR :

GHSR1a

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.77 nM Compound: 22	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	[PMID: 24967667]
HEK293	IC₅₀	1.1 nM Compound: 22	Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	[PMID: 24967667]
HEK293	IC₅₀	3.4 nM Compound: 22	Displacement of [125I]human ghrelin from rat GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method Displacement of [125I]human ghrelin from rat GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	[PMID: 24967667]

Chemical Information

CAS No. 1143020-91-0
Masse moléculaire 621.17
Formule C₂₇H₃₃ClN₆O₅S₂
SMILES

O=C(NC(NC1=NC2=CC=C(S(=O)(CCCN3CCN(C)CC3)=O)C=C2S1)=O)C4=CC(N5CCOCC5)=CC=C4Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. McCoull W, et al. Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem. 2014;57(14):6128-6140. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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AZ-GHS-22

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform GHSR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AZ-GHS-22 Related Classifications

HY-137061 Related Classifications