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Cat. No.: HY-108482

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CP-96,345

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CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation.

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Pureté: 99.9%
CAS No.: 132746-60-2
Formule: C₂₈H₃₂N₂O
Masse moléculaire:412.57

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CP-96,345 Chemical Structure

CAS No.: 132746-60-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Tachykinin, Substance P receptor^[1]

Voir tous les produits spécifiques à Isoform Neurokinin Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	46.83 μM Compound: CP-96345	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28710964]
CHO	IC₅₀	0.45 nM Compound: CP-96345	Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P. Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.	[PMID: 7535362]
CHO	IC₅₀	0.5 nM Compound: CP-96345	Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P. Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.	[PMID: 7535362]
CHO	IC₅₀	22 nM Compound: CP-96345	Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P. Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.	[PMID: 7535362]
CHO	IC₅₀	0.2 nM Compound: 1, (CP-96345)	Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells	[PMID: 8393115]
CHO	IC₅₀	0.4 nM Compound: 2	Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells	[PMID: 8627597]
CHO	IC₅₀	0.5 nM Compound: CP-96345	Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells	10.1016/0960-894X(95)00080-D
CHO	IC₅₀	0.7 nM Compound: CP-96345	Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells	10.1016/S0960-894X(01)80280-8
CHO	IC₅₀	0.5 nM Compound: 1	Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells	10.1016/S0960-894X(01)80747-2
IM-9	IC₅₀	0.77 nM Compound: 3, (CP-96345)	Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand	[PMID: 1378901]
IM-9	IC₅₀	0.48 nM Compound: 1	Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand	[PMID: 7520943]
IM-9	IC₅₀	0.35 nM Compound: 1	Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand	[PMID: 8576917]
IM-9	IC₅₀	0.33 nM Compound: CP-96345	Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP	10.1016/0960-894X(96)00148-5
IM-9	IC₅₀	4.2 nM Compound: CP-96345	Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells	10.1016/S0960-894X(00)80693-9
IM-9	IC₅₀	0.52 nM Compound: CP-96345	Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells	10.1016/S0960-894X(01)80246-8
IM-9	IC₅₀	2 nM Compound: CP-96345	Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells	10.1016/S0960-894X(01)80859-3
MRC5	IC₅₀	57.9 μM Compound: CP-96345	Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay	[PMID: 28710964]
U-373MG ATCC	IC₅₀	9 nM Compound: 1, (CP-96345)	Compound was tested for inhibition of substance P induced phosphatidyl inositol turnover in human U-373 cells Compound was tested for inhibition of substance P induced phosphatidyl inositol turnover in human U-373 cells	10.1016/0960-894X(96)00287-9

Chemical Information

CAS No. 132746-60-2
Appearance Solid
Masse moléculaire 412.57
Formule C₂₈H₃₂N₂O
Color White to light yellow
SMILES

COC1=C(C=CC=C1)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lembeck F, et al. The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br J Pharmacol. 1992;105(3):527-530. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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CP-96,345

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Neuronal Signaling Compound Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Voir tous les produits spécifiques à Isoform Neurokinin Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CP-96,345

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Neuronal Signaling Compound Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Voir tous les produits spécifiques à Isoform Neurokinin Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CP-96,345 Related Classifications

HY-108482 Related Classifications