2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist

J J Hale  ¹ ,  S G Mills ,  M MacCoss ,  S K Shah ,  H Qi ,  D J Mathre ,  M A Cascieri ,  S Sadowski ,  C D Strader ,  D E MacIntyre ,  J M Metzger