country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

CHD3 - chromodomain helicase DNA binding protein 3 Gene

Also Known as ZFH; Mi-2a; SNIBCPS; Mi2-ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1107

About CHD3

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,884,796-7,912,755 (from NCBI)

This gene has 23 transcripts (splice variants), 201 orthologues, 30 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 26.5), brain (RPKM 24.4) and 24 other tissues.

Summary

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

CHD3 Products (3)

mRNA	Protein	Name
NM_001005271.3	NP_001005271.2	chromodomain-helicase-DNA-binding protein 3 isoform 3
NM_001005273.3	NP_001005273.1	chromodomain-helicase-DNA-binding protein 3 isoform 1
NM_005852.4	NP_005843.2	chromodomain-helicase-DNA-binding protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	28977666	GOA
enables ATP-dependent chromatin remodeler activity	IDA IDA: Inferred from direct assay	28977666	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9804427	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	27068747	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in centrosome cycle	IDA IDA: Inferred from direct assay	17626165	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	30397230	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27068747	GOA
involved in spindle organization	IDA IDA: Inferred from direct assay	17626165	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	17827154	GOA
part of NuRD complex	IPI IPI: Inferred from physical interaction	27068747	GOA
located in PML body	IDA IDA: Inferred from direct assay	27068747	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17626165	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17626165	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22720776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHD3 Protein Structure

CHDNT

PHD

Chromo

SNF2_N

Helicase_C

DUF1087

DUF1086

CHDCT2

0
400
800
1200
1600
2000 a.a.

Protein Preferred Names	Protein Names
chromodomain-helicase-DNA-binding protein 3	ATP-dependent helicase CHD3

CHD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CHD3	Q12873	DDX5	Homo sapiens	P17844	Anti Bait CoIP	20676135
Intra	CHD3	Q12873	HTT	Homo sapiens	P42858	Y2H	15383276
Intra	CHD3	Q12873	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	CHD3	Q12873	GIT1	Homo sapiens	Q9Y2X7	Pull Down	15383276
Intra	CHD3	Q12873	GIT1	Homo sapiens	Q9Y2X7	Y2H	15383276
Intra	CHD3	Q12873	SUMO2	Homo sapiens	P61956	Y2H	15383276
Intra	CHD3	Q12873	PRPF40A	Homo sapiens	O75400	Y2H	15383276
Intra	CHD3	Q12873	PRPF40A	Homo sapiens	O75400	Pull Down	15383276
Intra	CHD3	Q12873	SERBP1	Homo sapiens	Q8NC51	Y2H	12505151

Cross: Cross-species interaction Intra: Intraspecies interaction

CHD3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81264	CHD3 Antibody (YA944)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P81264A	CHD3 Antibody (YA945)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Snijders Blok-Campeau Syndrome	SNIBCPS Intellectual Developmental Disorder With Macrocephaly, Speech Delay, And Dysmorphic Facies Iddmsf Chd3-Related Developmental Delay-Speech Delay-Intellectual Disability-Abnormalities Of Vision-Facial Dysmorphism Syndrome
Dermatomyositis	Amyopathic Dermatomyositis Dermatopolymyositis Adult Dermatomyositis Polymyositis With Skin Involvement Adult Type Dermatomyositis Petges-Clejat Syndrome
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Apraxia	Apraxias Dyspraxia
Myasthenic Syndrome, Congenital, 1a, Slow-Channel	Congenital Myasthenic Syndrome 1a Congenital Myasthenic Syndrome 2a CMS1A Cms Iia Congenital Myasthenic Syndrome Type Iia Cms2a Myasthenic Syndrome, Congenital, Type Iia, Formerly Cms2a, Formerly Cms Iia, Formerly Congenital Myasthenic Syndrome 1a, Slow-Channel Congenital Myasthenic Syndrome 2a Slow-Channel Congenital Myasthenic Syndrome Post-Synaptic Slow-Channel Myasthenic Syndrome, Congenital, Slow-Channel Sccms Myasthenic Syndrome, Congenital, Type 1a, Slow-Channel Myasthenic Syndrome, Congenital, Postsynaptic Slow-Channel Myasthenic Syndromes, Congenital, Slow Channel
Charge Syndrome	Charge Association Hall-Hittner Syndrome Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies Hhs Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome CHARGES
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS02608	CHD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21310	Chd3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27829	Chd3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHD3	VGNC	VGNC:39201
Mus musculus	CHD3	MGD	MGI:1344395
Rattus norvegicus	CHD3	RGD	RGD:1311923
Felis catus	CHD3	VGNC	VGNC:60845
Bos taurus	CHD3	VGNC	VGNC:27279
Others	CHD3	NCBI