DDX5 - DEAD-box helicase 5 Gene

Homo sapiens

Also known as p68; HLR1; G17P1; HUMP68

Gene ID: 1655 | Gene type: protein coding

About DDX5

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:64,498,254-64,506,866 (from NCBI)

This gene has 41 transcripts (splice variants), 275 orthologues, 38 paralogues and is associated with 48 phenotypes. Ubiquitous expression in bone marrow (RPKM 190.1), lymph node (RPKM 152.4) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in Cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]

DDX5 Products(4)

mRNA	Protein	Name
NM_001320595.2	NP_001307524.1	probable ATP-dependent RNA helicase DDX5 isoform a
NM_001320596.3	NP_001307525.1	probable ATP-dependent RNA helicase DDX5 isoform a
NM_001320597.2	NP_001307526.1	probable ATP-dependent RNA helicase DDX5 isoform b
NM_004396.5	NP_004387.1	probable ATP-dependent RNA helicase DDX5 isoform a

DDX5 Protein Structure

DEAD

Helicase_C

P68HR

0
100
200
300
400
500
614 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX5

ATP-dependent RNA helicase DDX5

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12486	FL118		99.40%	Unkown
HY-160438A	PBX-7011 mesylate	Inhibitor	/	Unkown
HY-160438B	PBX-7011 TFA	Degrader	/	Unkown
HY-160438	PBX-7011		/	Unkown
HY-RS03655	DDX5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDX5	RGD	RGD:619906
Canis familiaris	DDX5	VGNC	VGNC:39862
Bos taurus	DDX5	VGNC	VGNC:27972
Mus musculus	DDX5	MGD	MGI:105037
Macaca mulatta	DDX5	VGNC	VGNC:71763
Felis catus	DDX5	VGNC	VGNC:97398
Others	DDX5	NCBI

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