DROSHA - drosha ribonuclease III Gene

Homo sapiens

Also known as RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976

Gene ID: 29102 | Gene type: protein coding

About DROSHA

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,400,494-31,532,093 (from NCBI)

This gene has 20 transcripts (splice variants), 199 orthologues and is associated with 90 phenotypes. Ubiquitous expression in brain (RPKM 9.5), ovary (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of MicroRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary MicroRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney Cancer. [provided by RefSeq, Sep 2016]

DROSHA Products(3)

mRNA	Protein	Name
NM_001100412.2	NP_001093882.1	ribonuclease 3 isoform 2
NM_001382508.1	NP_001369437.1	ribonuclease 3 isoform 1
NM_013235.5	NP_037367.3	ribonuclease 3 isoform 1

DROSHA Protein Structure

Ribonucleas_3_3

Ribonuclease_3

dsrm

0
300
600
900
1200
1374 a.a.

Protein Preferred Names

Protein Names

ribonuclease 3

RNase III

Related Diseases

Diseases

Alias

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

Pineal Region Choriocarcinoma

Pineal Choriocarcinoma

Dicer1 Syndrome

Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome	Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome
Ppb Familial Tumor Susceptibility Syndrome	Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome
Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility	Dicer1-Related Pleuropulmonary Blastoma
Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome	Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome
Ppbftds	Doid:0081063

Acrocephalopolysyndactyly Type Iii

Sakati Syndrome	Sakati-Nyhan Syndrome
Acps With Leg Hypoplasia	Acps Iii
Acrocephalopolysyndactyly Type 3	Sakati-Nyhan-Tisdale Syndrome

Pineoblastoma

Pineal Pnet	Pinealoma
Pineal Gland Neoplasm	Pineocytoma
Tumor Of The Pineal Region

Pineal Gland Cancer

Tumor Of The Pineal Region	Malignant Pineal Region Tumor
Malignant Tumor Of Pineal Gland	Neoplasm Of Pineal Gland
Neoplasm Of The Pineal Region	Pineal Body Neoplasm
Pineocytic Tumor	Malignant Neoplasm Of Pineal Gland
Pineal Gland Neoplasm	Pineocytoma

Pineal Parenchymal Tumor Of Intermediate Differentiation

Pineal Parenchymal Tumour Of Intermediate Differentiation	Pineal Parenchymal Tumors Of Intermediate Differentiation
Pptid

Kidney Cancer

Renal Cancer	Renal Carcinoma
Kidney Neoplasm	Malignant Neoplasm Of Kidney Except Pelvis
Malignant Tumour Of Kidney	Kidney Neoplasms
Cancer, Kidney	Cancer, Renal
Malignant Neoplasm Of Kidney	Renal Cell Carcinoma

Pleuropulmonary Blastoma

PPB	Ppb Familial Tumor And Dysplasia Syndrome
Ppbftds	Pulmonary Blastoma
Blastoma, Pleuropulmonary	Dicer1 Syndrome
Respiratory Tract Neoplasms

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Maxillonasal Dysplasia, Binder Type

Binder Syndrome	Binder Type Maxillonasal Dysplasia
Maxillonasal Dysplasia	Maxillonasal Dysostosis

Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Gall Duct
Ca Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Biliary Passages
Intrahepatic Bile Duct Carcinoma

X-Linked Hereditary Ataxia

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Chromosomal Deletion Syndrome

Premature Ovarian Failure 1

Ovarian Failure, Premature	Fmr1-Related Primary Ovarian Insufficiency
Fragile X-Associated Primary Ovarian Insufficiency	POF1
Pofx	Hypergonadotropic Ovarian Failure, X-Linked
Pof	Primary Ovarian Insufficiency, Fragile X-Associated
Primary Ovarian Insufficiency 1	Ovarian Failure Premature
Premature Ovarian Failure, X-Linked	Fragile X Premature Ovarian Failure
Fmr1-Related Premature Ovarian Failure	Familial Premature Ovarian Failure
Idiopathic Familial Premature Ovarian Failure	Fxpoi
X-Linked Hypergonadotropic Ovarian Failure	Hypergonadotropic Ovarian Failure X-Linked
Poi	Premature Ovarian Failure X-Linked
Primary Ovarian Insufficiency	Premature Ovarian Failure-1
Ovarian Failure, Premature, Type 1	Premature Ovarian Failure, Familial
Premature Menopause	Primary Hypogonadism
Turner Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Feingold Syndrome 1

Feingold Syndrome	Oculodigitoesophagoduodenal Syndrome
Oded Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum	FGLDS1
Mmt Syndrome	Brunner-Winter Syndrome
Feingold Syndrome Type 1	Oded
Moded	Fglds
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome	Moded Syndrome
Oculo-Digito-Esophageal-Duodenal Syndrome	Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome
Microcephaly And Digital Abnormalities With Normal Intelligence	Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum
Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Oculo-Digito-Esophagoduodental Syndrome	Fs
Mmt	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome	Brunner-Winter Syndrome Type 1
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1	Fs1
Mmt Type 1	Moded Syndrome Type 1
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1	Oded Syndrome Type 1
Oculo-Digito-Esophageal-Duodenal Syndrome Type 1	Feingold Syndrome, Type 1

Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome	WTS
Mrxs6	X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome
Mrxswt	Wilson-Turner X-Linked Mental Retardation Syndrome
Mental Retardation, X-Linked, Syndromic 6	Mental Retardation, X-Linked, With Gynecomastia And Obesity
Intellectual Disability, X-Linked, Syndromic 6	Intellectual Disability, X-Linked, With Gynecomastia And Obesity
Wilson Turner Intellectual Disability Syndrome	X-Linked Intellectual Disability - Gynecomastia - Obesity

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17624	Framycetin	Inhibitor	/	Unkown
HY-17624A	Framycetin sulfate	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132598	Miravirsen	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15843	MIR96-IN-1		99.57%	Unkown
HY-RS04012	DROSHA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DROSHA	VGNC	VGNC:28211
Mus musculus	DROSHA	MGD	MGI:1261425
Felis catus	DROSHA	VGNC	VGNC:61632
Macaca mulatta	DROSHA	VGNC	VGNC:71854
Rattus norvegicus	DROSHA	RGD	RGD:1307626

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