DROSHA - drosha ribonuclease III Gene

Also Known as RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29102

About DROSHA

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,400,494-31,532,093 (from NCBI)

This gene has 20 transcripts (splice variants), 199 orthologues and is associated with 90 phenotypes. Ubiquitous expression in brain (RPKM 9.5), ovary (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of MicroRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary MicroRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney Cancer. [provided by RefSeq, Sep 2016]

DROSHA Products (3)

mRNA	Protein	Name
NM_001100412.2	NP_001093882.1	ribonuclease 3 isoform 2
NM_001382508.1	NP_001369437.1	ribonuclease 3 isoform 1
NM_013235.5	NP_037367.3	ribonuclease 3 isoform 1

DROSHA Protein Structure

Ribonucleas_3_3

Ribonuclease_3

dsrm

0
300
600
900
1200
1374 a.a.

Protein Preferred Names	Protein Names
ribonuclease 3	RNase III

DROSHA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DROSHA	Q9NRR4	SMAD1	Homo sapiens	Q15797	Anti Bait CoIP	18548003
Intra	DROSHA	Q9NRR4	DDX5	Homo sapiens	P17844	Anti Tag CoIP	19626115
Intra	DROSHA	Q9NRR4	DDX5	Homo sapiens	P17844	Anti Bait CoIP	22222205
Intra	DROSHA	Q9NRR4	DDX5	Homo sapiens	P17844	Anti Bait CoIP	19626115
Intra	DROSHA	Q9NRR4	DDX5	Homo sapiens	P17844	Anti Bait CoIP	18548003
Intra	DROSHA	Q9NRR4	DDX5	Homo sapiens	P17844	Anti Tag CoIP	18548003
Intra	DROSHA	Q9NRR4	TP53	Homo sapiens	P04637	Anti Bait CoIP	19626115
Intra	DROSHA	Q9NRR4	TP53	Homo sapiens	P04637	Anti Tag CoIP	19626115
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Bait CoIP	22222205
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Tag CoIP	19626115
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Tag CoIP	24581491
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Tag CoIP	22796965
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Bait CoIP	19626115
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Tag CoIP	23995758
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Tag CoIP	15574589
Intra	DROSHA	Q9NRR4	DGCR8	Homo sapiens	Q8WYQ5	Anti Bait CoIP	35914814

Cross: Cross-species interaction Intra: Intraspecies interaction

DROSHA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80110	Drosha Antibody (YA472)	WB, ICC/IF, IHC-P, FC	Human

Related Diseases

Diseases	Alias
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
Pineal Region Choriocarcinoma	Pineal Choriocarcinoma
Dicer1 Syndrome	Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome Ppb Familial Tumor Susceptibility Syndrome Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Dicer1-Related Pleuropulmonary Blastoma Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome Ppbftds Doid:0081063
Acrocephalopolysyndactyly Type Iii	Sakati Syndrome Sakati-Nyhan Syndrome Acps With Leg Hypoplasia Acps Iii Acrocephalopolysyndactyly Type 3 Sakati-Nyhan-Tisdale Syndrome
Pineoblastoma	Pineal Pnet Pinealoma Pineal Gland Neoplasm Pineocytoma Tumor Of The Pineal Region
Pineal Gland Cancer	Tumor Of The Pineal Region Malignant Pineal Region Tumor Malignant Tumor Of Pineal Gland Neoplasm Of Pineal Gland Neoplasm Of The Pineal Region Pineal Body Neoplasm Pineocytic Tumor Malignant Neoplasm Of Pineal Gland Pineal Gland Neoplasm Pineocytoma
Pineal Parenchymal Tumor Of Intermediate Differentiation	Pineal Parenchymal Tumour Of Intermediate Differentiation Pineal Parenchymal Tumors Of Intermediate Differentiation Pptid
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Pleuropulmonary Blastoma	PPB Ppb Familial Tumor And Dysplasia Syndrome Ppbftds Pulmonary Blastoma Blastoma, Pleuropulmonary Dicer1 Syndrome Respiratory Tract Neoplasms
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Maxillonasal Dysplasia, Binder Type	Binder Syndrome Binder Type Maxillonasal Dysplasia Maxillonasal Dysplasia Maxillonasal Dysostosis
Intrahepatic Gall Duct Cancer	Malignant Neoplasm Of Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Gall Duct Ca Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Biliary Passages Intrahepatic Bile Duct Carcinoma
X-Linked Hereditary Ataxia
Fragile X-Associated Tremor/Ataxia Syndrome	Fxtas Syndrome Fragile X Tremor/Ataxia Syndrome Fxtas
Chromosomal Deletion Syndrome
Premature Ovarian Failure 1	Ovarian Failure, Premature Fmr1-Related Primary Ovarian Insufficiency Fragile X-Associated Primary Ovarian Insufficiency POF1 Pofx Hypergonadotropic Ovarian Failure, X-Linked Pof Primary Ovarian Insufficiency, Fragile X-Associated Primary Ovarian Insufficiency 1 Ovarian Failure Premature Premature Ovarian Failure, X-Linked Fragile X Premature Ovarian Failure Fmr1-Related Premature Ovarian Failure Familial Premature Ovarian Failure Idiopathic Familial Premature Ovarian Failure Fxpoi X-Linked Hypergonadotropic Ovarian Failure Hypergonadotropic Ovarian Failure X-Linked Poi Premature Ovarian Failure X-Linked Primary Ovarian Insufficiency Premature Ovarian Failure-1 Ovarian Failure, Premature, Type 1 Premature Ovarian Failure, Familial Premature Menopause Primary Hypogonadism Turner Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Feingold Syndrome 1	Feingold Syndrome Oculodigitoesophagoduodenal Syndrome Oded Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum FGLDS1 Mmt Syndrome Brunner-Winter Syndrome Feingold Syndrome Type 1 Oded Moded Fglds Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Moded Syndrome Oculo-Digito-Esophageal-Duodenal Syndrome Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome Microcephaly And Digital Abnormalities With Normal Intelligence Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Oculo-Digito-Esophagoduodental Syndrome Fs Mmt Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Brunner-Winter Syndrome Type 1 Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1 Fs1 Mmt Type 1 Moded Syndrome Type 1 Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1 Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1 Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1 Oded Syndrome Type 1 Oculo-Digito-Esophageal-Duodenal Syndrome Type 1 Feingold Syndrome, Type 1
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17624	Framycetin	Inhibitor	/	Unkown
HY-17624A	Framycetin sulfate	Inhibitor	98.0%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132598A	Miravirsen sodium		99.44%	Phase 2
HY-132598	Miravirsen	Inhibitor	97.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15843	MIR96-IN-1		99.57%	Unkown
HY-RS04012	DROSHA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-17624S	Framycetin-d2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DROSHA	VGNC	VGNC:28211
Mus musculus	DROSHA	MGD	MGI:1261425
Felis catus	DROSHA	VGNC	VGNC:61632
Macaca mulatta	DROSHA	VGNC	VGNC:71854
Rattus norvegicus	DROSHA	RGD	RGD:1307626
Others	DROSHA	NCBI