DGCR8 - DGCR8 microprocessor complex subunit Gene

Also Known as Gy1; pasha; DGCRK6; C22orf12

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54487

About DGCR8

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,080,241-20,111,872 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and is associated with 63 phenotypes. Ubiquitous expression in testis (RPKM 13.8), placenta (RPKM 10.2) and 25 other tissues.

Summary

This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of MicroRNAs from the primary MicroRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

DGCR8 Products (2)

mRNA	Protein	Name
NM_001190326.2	NP_001177255.1	microprocessor complex subunit DGCR8 isoform 2
NM_022720.7	NP_073557.3	microprocessor complex subunit DGCR8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	17704815	GOA
enables heme binding	IDA IDA: Inferred from direct assay	24449907	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15574589	GOA
enables primary miRNA binding	IDA IDA: Inferred from direct assay	24910438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15574589	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15574589	GOA
enables protein-RNA adaptor activity	IDA IDA: Inferred from direct assay	15574589	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	34188037	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	34188037	GOA
involved in positive regulation of pre-miRNA processing	IDA IDA: Inferred from direct assay	15574589	GOA
acts upstream of or within primary miRNA processing	IDA IDA: Inferred from direct assay	15531877	GOA
involved in primary miRNA processing	IDA IDA: Inferred from direct assay	15574589	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of microprocessor complex	IDA IDA: Inferred from direct assay	15574589	GOA
part of microprocessor complex	IPI IPI: Inferred from physical interaction	24581491	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15574589	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGCR8 Protein Structure

dsrm

0
200
400
600
773 a.a.

Protein Preferred Names	Protein Names
microprocessor complex subunit DGCR8	DiGeorge syndrome critical region 8

DGCR8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DGCR8	Q8WYQ5	DROSHA	Homo sapiens	Q9NRR4	Anti Tag CoIP	22796965
Intra	DGCR8	Q8WYQ5	DROSHA	Homo sapiens	Q9NRR4	Anti Tag CoIP	33961781
Intra	DGCR8	Q8WYQ5	DROSHA	Homo sapiens	Q9NRR4	Anti Tag CoIP	26496610
Intra	DGCR8	Q8WYQ5	DROSHA	Homo sapiens	Q9NRR4	Anti Tag CoIP	15574589
Intra	DGCR8	Q8WYQ5	DROSHA	Homo sapiens	Q9NRR4	GMS	24581491
Intra	DGCR8	Q8WYQ5	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	DGCR8	Q8WYQ5	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	DGCR8	Q8WYQ5	SRPK1	Homo sapiens	Q96SB4	BiFC	23602568
Intra	DGCR8	Q8WYQ5	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	DGCR8	Q8WYQ5	DGCR8	Homo sapiens	Q8WYQ5	Anti Tag CoIP	15574589
Intra	DGCR8	Q8WYQ5	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	23602568
Intra	DGCR8	Q8WYQ5	DGCR8	Homo sapiens	Q8WYQ5	GMS	17159994

Cross: Cross-species interaction Intra: Intraspecies interaction

DGCR8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82935	DGCR8 Antibody (YA2680)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P82935A	DGCR8 Antibody (YA2680)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
Acrocephalopolysyndactyly Type Iii	Sakati Syndrome Sakati-Nyhan Syndrome Acps With Leg Hypoplasia Acps Iii Acrocephalopolysyndactyly Type 3 Sakati-Nyhan-Tisdale Syndrome
Chromosomal Deletion Syndrome
X-Linked Hereditary Ataxia
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Pineoblastoma	Pineal Pnet Pinealoma Pineal Gland Neoplasm Pineocytoma Tumor Of The Pineal Region
Fragile X-Associated Tremor/Ataxia Syndrome	Fxtas Syndrome Fragile X Tremor/Ataxia Syndrome Fxtas
Pineal Gland Cancer	Tumor Of The Pineal Region Malignant Pineal Region Tumor Malignant Tumor Of Pineal Gland Neoplasm Of Pineal Gland Neoplasm Of The Pineal Region Pineal Body Neoplasm Pineocytic Tumor Malignant Neoplasm Of Pineal Gland Pineal Gland Neoplasm Pineocytoma
Premature Ovarian Failure 1	Ovarian Failure, Premature Fmr1-Related Primary Ovarian Insufficiency Fragile X-Associated Primary Ovarian Insufficiency POF1 Pofx Hypergonadotropic Ovarian Failure, X-Linked Pof Primary Ovarian Insufficiency, Fragile X-Associated Primary Ovarian Insufficiency 1 Ovarian Failure Premature Premature Ovarian Failure, X-Linked Fragile X Premature Ovarian Failure Fmr1-Related Premature Ovarian Failure Familial Premature Ovarian Failure Idiopathic Familial Premature Ovarian Failure Fxpoi X-Linked Hypergonadotropic Ovarian Failure Hypergonadotropic Ovarian Failure X-Linked Poi Premature Ovarian Failure X-Linked Primary Ovarian Insufficiency Premature Ovarian Failure-1 Ovarian Failure, Premature, Type 1 Premature Ovarian Failure, Familial Premature Menopause Primary Hypogonadism Turner Syndrome
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease
Synchronous Bilateral Breast Carcinoma
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03714	DGCR8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21552	Dgcr8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28070	Dgcr8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DGCR8	RGD	RGD:1306365
Bos taurus	DGCR8	VGNC	VGNC:28023
Felis catus	DGCR8	VGNC	VGNC:61457
Mus musculus	DGCR8	MGD	MGI:2151114
Macaca mulatta	DGCR8	VGNC	VGNC:71779
Others	DGCR8	NCBI