EXOSC10 - exosome component 10 Gene

Also Known as p2; p3; p4; RRP6; PMSCL; Rrp6p; PM-Scl; PMSCL2; PM/Scl-100

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5394

About EXOSC10

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,066,618-11,099,869 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 18.4), testis (RPKM 18.0) and 25 other tissues.

Summary

Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via Telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC10 Products (2)

mRNA	Protein	Name
NM_001001998.3	NP_001001998.1	exosome component 10 isoform 1
NM_002685.4	NP_002676.1	exosome component 10 isoform 2

EXOSC10 Protein Structure

PMC2NT

DNA_pol_A_exo1

HRDC

0
200
400
600
800
885 a.a.

Protein Preferred Names	Protein Names
exosome component 10	P100 polymyositis-scleroderma overlap syndrome-associated autoantigen

EXOSC10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EXOSC10	Q01780	DDX5	Homo sapiens	P17844	Anti Bait CoIP	23143267
Intra	EXOSC10	Q01780	EXOSC7	Homo sapiens	Q15024	Anti Tag CoIP	11812149
Intra	EXOSC10	Q01780	EXOSC5	Homo sapiens	Q9NQT4	Anti Tag CoIP	11812149
Intra	EXOSC10	Q01780	EXOSC8	Homo sapiens	Q96B26	Y2H	15231747
Intra	EXOSC10	Q01780	MPHOSPH6	Homo sapiens	Q99547	Anti Bait CoIP	16396833
Intra	EXOSC10	Q01780	DIS3	Homo sapiens	Q9Y2L1	Y2H	15231747
Intra	EXOSC10	Q01780	C1D	Homo sapiens	Q13901	Anti Bait CoIP	17412707
Intra	EXOSC10	Q01780	C1D	Homo sapiens	Q13901	Pull Down	17412707
Intra	EXOSC10	Q01780	C1D	Homo sapiens	Q13901	Confocal	17412707

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Polymyositis	Pm - [Polymyositis]
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Diffuse Scleroderma	Diffuse Systemic Sclerosis Systemic Sclerosis, Diffuse Scleroderma, Diffuse Systemic Scleroderma Progressive System Sclerosis
Dyskeratosis Congenita, Autosomal Recessive 6	DKCB6 Autosomal Recessive Dyskeratosis Congenita 6 Dyskeratosis Congenita, Autosomal Recessive, 6 Dyskeratosis Congenita, Autosomal Recessive, Type 6
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Facial Hemiatrophy	Parry-Romberg Syndrome
Dyskinesia Of Esophagus	Esophageal Motility Disorders Dyskinesia Of Oesophagus Esophageal Dysmotility Esophageal Motility Disorder Oesophageal Dysmotility Oesophageal Motor Disorder Esophageal Spasm
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25
Pontocerebellar Hypoplasia, Type 1c	PCH1C Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia Pontocerebellar Hypoplasia Type 1c Pontocerebellar Hypoplasia 1c Doid:0112334 Hypoplasia, Pontocerebellar, Type 1c
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Localized Scleroderma	Morphea Localised Scleroderma Localized Fibrosing Scleroderma Circumscribed Scleroderma Localised Morphea Localised Morphoea Localized Morphea Scleroderma, Circumscribed Or Localised Scleroderma, Circumscribed Or Localized Scleroderma, Localized
Crest Syndrome
Gastric Antral Vascular Ectasia	Watermelon Stomach Gave
Splenic Tuberculosis	Tuberculosis, Splenic
Telangiectasis	Telangiectasia
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Collagen Disease	Collagen Diseases Collagen Disorder
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Muscle Tissue Disease
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Myopathy	Muscular Diseases Myopathies
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04597	EXOSC10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EXOSC10	VGNC	VGNC:28656
Mus musculus	EXOSC10	MGD	MGI:1355322
Canis familiaris	EXOSC10	VGNC	VGNC:40522
Felis catus	EXOSC10	VGNC	VGNC:68926
Rattus norvegicus	EXOSC10	RGD	RGD:1593248
Macaca mulatta	EXOSC10	VGNC	VGNC:72478
Others	EXOSC10	NCBI