DIS3 - DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Gene

Also Known as RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22894

About DIS3

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:72,752,169-72,781,900 (from NCBI)

This gene has 5 transcripts (splice variants), 238 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues.

Summary

Enables 3'-5'-exoribonuclease activity; Endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

DIS3 Products (4)

mRNA	Protein	Name
NM_001128226.3	NP_001121698.1	exosome complex exonuclease RRP44 isoform b
NM_001322348.2	NP_001309277.1	exosome complex exonuclease RRP44 isoform c
NM_001322349.2	NP_001309278.1	exosome complex exonuclease RRP44 isoform d
NM_014953.5	NP_055768.3	exosome complex exonuclease RRP44 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-5'-RNA exonuclease activity	IMP IMP: Inferred from mutant phenotype	20531386	GOA
enables endonuclease activity	IMP IMP: Inferred from mutant phenotype	20531386	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9562621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CUT catabolic process	IMP IMP: Inferred from mutant phenotype	19056938	GOA
involved in RNA catabolic process	IDA IDA: Inferred from direct assay	17174896	GOA
involved in RNA processing	IDA IDA: Inferred from direct assay	17174896	GOA
involved in rRNA catabolic process	IMP IMP: Inferred from mutant phenotype	20368444	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	20531386	GOA
part of nuclear exosome (RNase complex)	IDA IDA: Inferred from direct assay	20531386	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	20531386	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	20531389	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20531386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIS3 Protein Structure

PIN_4

RNB

0
200
400
600
800
958 a.a.

Protein Preferred Names	Protein Names
exosome complex exonuclease RRP44	DIS3 exosome endoribonuclease and 3'-5' exoribonuclease

DIS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DIS3	Q9Y2L1	EXOSC2	Homo sapiens	Q13868	Anti Bait CoIP	20531386
Intra	DIS3	Q9Y2L1	EXOSC2	Homo sapiens	Q13868	Anti Tag CoIP	33961781
Intra	DIS3	Q9Y2L1	EXOSC2	Homo sapiens	Q13868	TAP	20531386
Intra	DIS3	Q9Y2L1	EXOSC10	Homo sapiens	Q01780	Anti Bait CoIP	20531386
Intra	DIS3	Q9Y2L1	EXOSC10	Homo sapiens	Q01780	Anti Tag CoIP	21255825
Intra	DIS3	Q9Y2L1	EXOSC10	Homo sapiens	Q01780	Anti Tag CoIP	23756462
Intra	DIS3	Q9Y2L1	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	21255825

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Axenfeld-Rieger Syndrome, Type 2	Axenfeld-Rieger Syndrome Type 2 RIEG2 Rieger Syndrome, Type 2 Rieger Syndrome Type 2 Rieger Syndrome 2
Perlman Syndrome	Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor PRLMNS Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome Renal Hamartomas Nephroblastomatosis And Fetal Gigantism Nephroblastoma Fetal Macrosomia
Pontocerebellar Hypoplasia, Type 1b	Pontocerebellar Hypoplasia Type 1b PCH1B Pontocerebellar Hypoplasia 1b Hypoplasia, Pontocerebellar, Type 1b
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Smoldering Myeloma
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Colon Leiomyoma	Colonic Leiomyoma
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Nodular Malignant Melanoma	Nodular Melanoma
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171498	gDIS3-13	Inducer	96.75%	Unkown
HY-RS03778	DIS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03779	DIS3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03780	DIS3L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-173081	4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DIS3	RGD	RGD:1304646
Canis familiaris	DIS3	VGNC	VGNC:39962
Mus musculus	DIS3	MGD	MGI:1919912
Bos taurus	DIS3	VGNC	VGNC:28072
Felis catus	DIS3	VGNC	VGNC:61499
Macaca mulatta	DIS3	VGNC	VGNC:71687