EXOSC7 - exosome component 7 Gene

Also Known as p8; EAP1; RRP42; Rrp42p; hRrp42p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23016

About EXOSC7

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:44,976,244-45,012,668 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 11.2), skin (RPKM 10.6) and 25 other tissues.

Summary

Predicted to enable 3'-5'-exoribonuclease activity and RNA binding activity. Predicted to be involved in RNA metabolic process. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC7 Products (1)

mRNA Protein Name
NM_015004.4 NP_055819.2 exosome complex component RRP42

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables RNA exonuclease activity IDA
IDA: Inferred from direct assay
17174896 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11719186 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA catabolic process IDA
IDA: Inferred from direct assay
17174896 GOA
involved in RNA processing IDA
IDA: Inferred from direct assay
17174896 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
20531386 GOA
part of exosome (RNase complex) IDA
IDA: Inferred from direct assay
20531389 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
20531386 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20531386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOSC7 Protein Structure

RNase_PH

RNase_PH: 3' exoribonuclease family, domain 1 (32 - 166)

RNase_PH_C

RNase_PH_C: 3' exoribonuclease family, domain 2 (197 - 261)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

exosome complex component RRP42

  • exosome complex exonuclease RRP42

EXOSC7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EXOSC7 Q15024 EXOSC2 Homo sapiens Q13868
Anti Tag CoIP
33961781
Intra
EXOSC7 Q15024 EXOSC2 Homo sapiens Q13868
Anti Tag CoIP
28514442
Intra
EXOSC7 Q15024 EXOSC2 Homo sapiens Q13868
Y2H
12419256
Intra
EXOSC7 Q15024 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
21255825
Intra
EXOSC7 Q15024 EXOSC10 Homo sapiens Q01780
Y2H
15231747
Intra
EXOSC7 Q15024 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
33961781
Intra
EXOSC7 Q15024 EXOSC4 Homo sapiens Q9NPD3
Y2H
12419256
Intra
EXOSC7 Q15024 EXOSC4 Homo sapiens Q9NPD3
Anti Tag CoIP
33961781
Intra
EXOSC7 Q15024 EXOSC4 Homo sapiens Q9NPD3
Anti Tag CoIP
28514442
Intra
EXOSC7 Q15024 EXOSC1 Homo sapiens Q9Y3B2
Y2H
12419256
Intra
EXOSC7 Q15024 EXOSC1 Homo sapiens Q9Y3B2
Pull Down
11812149
Intra
EXOSC7 Q15024 IP6K1 Homo sapiens Q92551
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

EXOSC7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87056 RRP42 Antibody (YA6749) WB, IHC-P Human, Zebrafish

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 1c

  • PCH1C

  • Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

  • Pontocerebellar Hypoplasia Type 1c

  • Pontocerebellar Hypoplasia 1c

  • Doid:0112334

  • Hypoplasia, Pontocerebellar, Type 1c
Trichohepatoenteric Syndrome 1

  • Trichohepatoenteric Syndrome

  • Syndromic Diarrhea

  • Tricho-Hepato-Enteric Syndrome

  • Sd/The

  • Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

  • THES1

  • Phenotypic Diarrhea

  • Thes

  • Phenotypic Diarrhea Of Infancy

  • Diarrhea, Syndromic

  • Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

  • Intractable Diarrhea With Phenotypic Anomalies

  • Syndromatic Diarrhea

  • Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1b

  • Pontocerebellar Hypoplasia Type 1b

  • PCH1B

  • Pontocerebellar Hypoplasia 1b

  • Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia, Type 1e

  • Pontocerebellar Hypoplasia Type 1

  • PCH1E

  • Norman Disease

  • Pch1

  • Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

  • Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

  • Pontocerebellar Hypoplasia Type 1e

  • Pontocerebellar Hypoplasia 1e

  • Doid:0112322

  • Doid:0112330
Trichohepatoenteric Syndrome 2

  • THES2
Pontocerebellar Hypoplasia

  • Pch

  • Congenital Pontocerebellar Hypoplasia

  • Opch

  • Hypoplasia, Pontocerebellar

  • Pontoneocerebellar Hypoplasia

  • Nonsyndromic Pontocerebellar Hypoplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04603 EXOSC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EXOSC7 MGD MGI:1913696
Macaca mulatta EXOSC7 VGNC VGNC:72383
Canis familiaris EXOSC7 VGNC VGNC:40527
Rattus norvegicus EXOSC7 RGD RGD:1309758
Felis catus EXOSC7 VGNC VGNC:62009
Bos taurus EXOSC7 VGNC VGNC:28661
Others EXOSC7 NCBI