RRP42 Antibody (YA6749)
(Synonyms: EAP1 antibody; EXOS7_HUMAN antibody; Exosc7 antibody; Exosome complex component RRP42 antibody; Exosome complex exonuclease RRP42 antibody; Exosome component 7 antibody; FLJ26543 antibody; hRrp42p antibody; KIAA0116 antibody; p8 antibody; EAP1 antibody; EXOS7_HUMAN antibody; Exosc7 antibody; Exosome complex component RRP42 antibody; Exosome complex exonuclease RRP42 antibody; Exosome component 7 antibody; FLJ26543 antibody; hRrp42p antibody; KIAA0116 antibody; p8 antibody; Ribosomal RNA processing protein 42 antibody; Ribosomal RNA-processing protein 42 antibody; RRP42 antibody; Rrp42p antibody; )RRP42 Antibody (YA6749) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RRP42.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Zebrafish
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:5000 | 1:50-1:200 |
Product Details
RRP42 Antibody (YA6749) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RRP42.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Zebrafish
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Observed Molecular WeightObserved band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Synthetic peptide within C-terminal Human RRP42.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RRP42 is a Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes
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Subcellular Localization
Nucleus, nucleolus,Cytoplasm,Nucleus
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Subunit
Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC2 and EXOSC4 (PubMed:29906447, PubMed:30047866)
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SwissProt ID
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Synonyms
EAP1 antibody; EXOS7_HUMAN antibody; Exosc7 antibody; Exosome complex component RRP42 antibody; Exosome complex exonuclease RRP42 antibody; Exosome component 7 antibody; FLJ26543 antibody; hRrp42p antibody; KIAA0116 antibody; p8 antibody; EAP1 antibody; EXOS7_HUMAN antibody; Exosc7 antibody; Exosome complex component RRP42 antibody; Exosome complex exonuclease RRP42 antibody; Exosome component 7 antibody; FLJ26543 antibody; hRrp42p antibody; KIAA0116 antibody; p8 antibody; Ribosomal RNA processing protein 42 antibody; Ribosomal RNA-processing protein 42 antibody; RRP42 antibody; Rrp42p antibody;
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