IPO11 - importin 11 Gene

Also Known as RanBP11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51194

About IPO11

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:62,412,763-62,628,582 (from NCBI)

This gene has 14 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 6.7) and 25 other tissues.

Summary

Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

IPO11 Products (2)

mRNA Protein Name
NM_001134779.2 NP_001128251.1 importin-11 isoform 1
NM_016338.5 NP_057422.3 importin-11 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPO11 Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (28 - 97)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
Protein Preferred Names Protein Names

importin-11

  • Ran binding protein 11

IPO11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IPO11 Q9UI26 DDX5 Homo sapiens P17844
Anti Tag CoIP
35271311
Intra
IPO11 Q9UI26 EIF4A2 Homo sapiens Q14240
Y2H Array
25416956
Intra
IPO11 Q9UI26 EIF4A2 Homo sapiens Q14240
Validated Y2H
25416956
Intra
IPO11 Q9UI26 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06866 IPO11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IPO11 VGNC VGNC:62953
Canis familiaris IPO11 VGNC VGNC:49760
Bos taurus IPO11 VGNC VGNC:50068
Macaca mulatta IPO11 VGNC VGNC:73633
Mus musculus IPO11 MGD MGI:2442377
Others IPO11 NCBI