SERBP1 - SERPINE1 mRNA binding protein 1 Gene

Also Known as CGI-55; CHD3IP; HABP4L; PAIRBP1; PAI-RBP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26135

About SERBP1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,407,810-67,430,402 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 40.3), thyroid (RPKM 34.9) and 25 other tissues.

Summary

Enables SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SERBP1 Products (4)

mRNA Protein Name
NM_001018067.2 NP_001018077.1 plasminogen activator inhibitor 1 RNA-binding protein isoform 1
NM_001018068.2 NP_001018078.1 plasminogen activator inhibitor 1 RNA-binding protein isoform 2
NM_001018069.2 NP_001018079.1 plasminogen activator inhibitor 1 RNA-binding protein isoform 3
NM_015640.4 NP_056455.3 plasminogen activator inhibitor 1 RNA-binding protein isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding EXP
EXP: Inferred from Experiment
34631798 GOA
enables SUMO binding IDA
IDA: Inferred from direct assay
28695742 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
11001948 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12505151 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
23636399 GOA
enables translation repressor activity IDA
IDA: Inferred from direct assay
36691768 GOA
Biological Process GO Annotation Evidence References Source
involved in PML body organization IDA
IDA: Inferred from direct assay
28695742 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
36691768 GOA
involved in ribosome hibernation IDA
IDA: Inferred from direct assay
36691768 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16879614 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16879614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERBP1 Protein Structure

HABP4_PAI-RBP1

HABP4_PAI-RBP1: Hyaluronan / mRNA binding family (189 - 314)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
Protein Preferred Names Protein Names

plasminogen activator inhibitor 1 RNA-binding protein

  • PAI-1 mRNA binding protein

SERBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERBP1 Q8NC51 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
SERBP1 Q8NC51 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
SERBP1 Q8NC51 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
SERBP1 Q8NC51 SERPINH1 Homo sapiens P50454
Validated Y2H
32814053
Intra
SERBP1 Q8NC51 SERPINH1 Homo sapiens P50454
Y2H Array
32814053
Intra
SERBP1 Q8NC51 SERPINH1 Homo sapiens P50454
Y2H Pooling
32814053
Intra
SERBP1 Q8NC51 CHD3 Homo sapiens Q12873
Y2H
12505151
Intra
SERBP1 Q8NC51 CHD3 Homo sapiens Q12873
Anti Bait CoIP
12505151
Intra
SERBP1 Q8NC51 CHD3 Homo sapiens Q12873
Pull Down
12505151
Intra
SERBP1 Q8NC51 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
SERBP1 Q8NC51 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
SERBP1 Q8NC51 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
SERBP1 Q8NC51 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
SERBP1 Q8NC51 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
SERBP1 Q8NC51 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12687 SERBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SERBP1 VGNC VGNC:46018
Felis catus SERBP1 VGNC VGNC:65016
Bos taurus SERBP1 VGNC VGNC:34461
Mus musculus SERBP1 MGD MGI:1914120
Macaca mulatta SERBP1 VGNC VGNC:81566
Rattus norvegicus SERBP1 RGD RGD:619907
Others SERBP1 NCBI