Bin1 - bridging integrator 1 Gene

Also Known as ALP-1; Amphl; SH3P9; BRAMP-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 30948

Summary

Enables aspartic-type endopeptidase inhibitor activity and Tau Protein binding activity. Involved in several processes, including negative regulation of amyloid precursor protein catabolic process; negative regulation of cation transmembrane transport; and regulation of heart contraction. Acts upstream of or within muscle cell differentiation. Located in several cellular components, including T-tubule; dendrite; and nuclear envelope. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; heart; and musculature. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Apr 2022]

Bin1 Products (3)

mRNA	Protein	Name
NM_001083334.1	NP_001076803.1	myc box-dependent-interacting protein 1 isoform 2
NM_001360876.1	NP_001347805.1	myc box-dependent-interacting protein 1 isoform 3
NM_009668.2	NP_033798.1	myc box-dependent-interacting protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables aspartic-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	27179792	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8782822	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	35263589	MGI
enables tau protein binding	IPI IPI: Inferred from physical interaction	23399914	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in T-tubule organization	IMP IMP: Inferred from mutant phenotype	24836577	MGI
acts upstream of or within muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	10036185	MGI
involved in negative regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	27179792	MGI
involved in negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	27179792	MGI
involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP IMP: Inferred from mutant phenotype	24836577	MGI
involved in negative regulation of potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24836577	MGI
involved in negative regulation of ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	24836577	MGI
involved in nucleus localization	IMP IMP: Inferred from mutant phenotype	26506308	MGI
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	24836577	MGI
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	24836577	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	35263589	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	11879655	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	11879655	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in T-tubule	IDA IDA: Inferred from direct assay	24836577	MGI
located in axon	IDA IDA: Inferred from direct assay	32552912	MGI
located in dendrite	IDA IDA: Inferred from direct assay	32552912	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11879655	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11879655	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	26506308	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8782822	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	30967682	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	30967682	MGI
is active in synapse	EXP EXP: Inferred from Experiment	24534009	MGI
is active in synapse	IDA IDA: Inferred from direct assay	24534009	MGI
located in vesicle	IDA IDA: Inferred from direct assay	32552912	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myc box-dependent-interacting protein 1	SH3 domain-containing protein 9 amphiphysin 2 amphiphysin II amphiphysin-like protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-10704	PTP1B-IN-1	Inhibitor	99.71%	Unkown
HY-139560	KDM2B-IN-1	Inhibitor	99.49%	Unkown
HY-126246	CDC25B-IN-1	Inhibitor	98.12%	Unkown
HY-163285	PDE3B-IN-1	Inhibitor	99.60%	Unkown
HY-135711	PDE8B-IN-1		99.91%	Unkown
HY-147646	CDK1/Cyc B-IN-1		98.47%	Unkown
HY-136556	Factor B-IN-1	Inhibitor	/	Unkown
HY-162811	LAG-3 biner 1		97.08%	Unkown
HY-117848	PDE8B-IN-1 hydrochloride	Inhibitor	/	Unkown
HY-142957	NaPi2b-IN-1	Inhibitor	/	Unkown
HY-145695	Dual AChE-MAO B-IN-1	Inhibitor	/	Unkown
HY-147945	DNA gyrase B-IN-1	Inhibitor	/	Unkown
HY-168185	α-glucosidase/PTP1B-IN-1	Inhibitor	/	Unkown
HY-176762	TOP3B-IN-1	Inhibitor	/	Unkown
HY-179109	EIF2B-IN-1	Inhibitor	/	Unkown
HY-182008	NEURL1B-IN-1		/	Unkown
HY-RS01504	BIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-170412	Cox B-IN-1	Inhibitor	/	Unkown
HY-170810	E.coli Gyrase B-IN-1	Inhibitor	/	Unkown
HY-181715	PBP1b-IN-1	Inhibitor	/	Unkown
HY-RS18913	Bin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25404	Bin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bin1	NCBI	NCBI:274