CLIC5 - chloride intracellular channel 5 Gene

Also Known as MST130; DFNB102; DFNB103; MSTP130

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53405

About CLIC5

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:45,880,827-46,129,819 (from NCBI)

This gene has 14 transcripts (splice variants), 242 orthologues, 14 paralogues and is associated with 2 phenotypes. Biased expression in lung (RPKM 21.7), heart (RPKM 20.0) and 10 other tissues.

Summary

This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

CLIC5 Products (5)

mRNA Protein Name
NM_001114086.2 NP_001107558.1 chloride intracellular channel protein 5 isoform a
NM_001256023.2 NP_001242952.1 chloride intracellular channel protein 5 isoform c
NM_001370649.1 NP_001357578.1 chloride intracellular channel protein 5 isoform d
NM_001370650.1 NP_001357579.1 chloride intracellular channel protein 5 isoform a
NM_016929.5 NP_058625.2 chloride intracellular channel protein 5 isoform b

CLIC5 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (191 - 254)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

chloride intracellular channel protein 5

Recombinant CLIC5 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70113 CLIC5 Protein, Human (His) Q9NZA1-2 (M1-S251) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 103

  • DFNB103

  • Autosomal Recessive Nonsyndromic Deafness 103

  • Autosomal Recessive Deafness 103

  • Deafness, Autosomal Recessive, 103

  • Deafness, Autosomal Recessive, Type 103
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

  • Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb

  • Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb

  • Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb

  • Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb

  • Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb

  • Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb

  • Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Nonsyndromic Deafness

  • Deafness, Autosomal Recessive, Nonsyndromic
Deafness, Autosomal Recessive
Retinitis Pigmentosa 20

  • RP20

  • Retinitis Pigmentosa, Type 20
Ischemic Neuropathy

  • Ischemic Peripheral Neuropathy
Retinitis Pigmentosa 25

  • RP25

  • Retinitis Pigmentosa-25

  • Retinitis Pigmentosa, Type 25
Deafness, Autosomal Recessive 102

  • DFNB102

  • Autosomal Recessive Nonsyndromic Deafness 102

  • Autosomal Recessive Deafness 102

  • Deafness, Autosomal Recessive, 102

  • Deafness, Autosomal Recessive, Type 102
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02807 CLIC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20382 Clic5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26892 Clic5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CLIC5 VGNC VGNC:102402
Canis familiaris CLIC5 VGNC VGNC:39341
Macaca mulatta CLIC5 VGNC VGNC:71171
Rattus norvegicus CLIC5 RGD RGD:620659
Mus musculus CLIC5 MGD MGI:1917912
Bos taurus CLIC5 VGNC VGNC:107286
Others CLIC5 NCBI