PRH1 - proline rich protein HaeIII subfamily 1 Gene

Also Known as PA; Db-s; PRH2; PIF-S; Pr1/Pr2; PRP-1/PRP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5554

About PRH1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,880,965-11,171,611 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 11 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 9623.1).

Summary

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

PRH1 Products (3)

mRNA Protein Name
NM_001291314.2 NP_001278243.1 salivary acidic proline-rich phosphoprotein 1月2日 isoform a preproprotein
NM_001291315.2 NP_001278244.1 salivary acidic proline-rich phosphoprotein 1月2日 isoform b
NM_001393989.1 NP_001380918.1 salivary acidic proline-rich phosphoprotein 1月2日 isoform a preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16203048 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRH1 Protein Structure

Pro-rich

Pro-rich: Proline-rich (1 - 161)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

salivary acidic proline-rich phosphoprotein 1/2

  • parotid acidic protein

PRH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PRH1 P02810 MUC7 Homo sapiens Q8TAX7
Y2H
16203048
Intra
PRH1 P02810 MUC7 Homo sapiens Q8TAX7
Far-WB
16203048
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Retinitis Pigmentosa 35

  • RP35

  • Retinitis Pigmentosa-35

  • Retinitis Pigmentosa, Type 35
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

  • Schinzel Phocomelia Syndrome

  • Aarrs

  • Limb/Pelvis-Hypoplasia/Aplasia Syndrome

  • LPHAS

  • Schinzel Type Phocomelia

  • Absence Of Ulna And Fibula With Severe Limb Deficiency

  • Al-Awadi/Raas-Rothschild Syndrome

  • Al Awadi-Raas-Rothschild Syndrome

  • Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

  • Aplasia/Hypoplasia Of Limbs And Pelvis

  • Congenital Absence Of Ulna And Fibula

  • Severe Limb Deficit

  • Phocomelia, Schinzel Type

  • Al-Awadi-Raas-Rothschild Syndrome

  • Ulna And Fibula Absence Of With Severe Limb Deficiency

  • Limb Pelvis Hypoplasia Aplasia Syndrome

  • Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

  • Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11091 PRH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown