ATL2 - atlastin GTPase 2 Gene

Also Known as aip-2; ARL3IP2; ARL6IP2; atlastin2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64225

About ATL2

Cytogenetic location: 2p22.2-p22.1 Genomic coordinates (GRCh38): 2:38,293,954-38,378,584 (from NCBI)

This gene has 18 transcripts (splice variants), 297 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 13.5), skin (RPKM 9.8) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Located in endoplasmic reticulum tubular network membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATL2 Products (10)

mRNA Protein Name
NM_001135673.4 NP_001129145.1 atlastin-2 isoform 2
NM_001308076.1 NP_001295005.1 atlastin-2 isoform 3
NM_001330458.2 NP_001317387.1 atlastin-2 isoform 4
NM_001330459.1 NP_001317388.1 atlastin-2 isoform 5
NM_001330460.1 NP_001317389.1 atlastin-2 isoform 6
NM_001330461.2 NP_001317390.1 atlastin-2 isoform 6
NM_001330462.1 NP_001317391.1 atlastin-2 isoform 7
NM_001330463.2 NP_001317392.1 atlastin-2 isoform 8
NM_001330464.2 NP_001317393.1 atlastin-2 isoform 9
NM_022374.5 NP_071769.2 atlastin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IDA
IDA: Inferred from direct assay
18270207 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
Biological Process GO Annotation Evidence Références Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
18270207 GOA
involved in endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
18270207 GOA
NOT involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
18270207 GOA
involved in endoplasmic reticulum tubular network membrane organization IMP
IMP: Inferred from mutant phenotype
27619977 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
18270207 GOA
Cellular Component GO Annotation Evidence Références Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18270207 GOA
located in endoplasmic reticulum tubular network membrane IDA
IDA: Inferred from direct assay
27619977 GOA
located in membrane IDA
IDA: Inferred from direct assay
18270207 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATL2 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (70 - 341)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (344 - 464)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 583 a.a.
Protein Preferred Names Protein Names

atlastin-2

  • ADP-ribosylation factor-like protein 6-interacting protein 2

ATL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
ATL2 Q8NHH9 Rtn3 Mus musculus Q9ES97-3
Anti Tag CoIP
19665976
Cross
ATL2 Q8NHH9 Reep5 Mus musculus Q60870
Anti Tag CoIP
19665976
Intra
ATL2 Q8NHH9 YWHAZ Homo sapiens P63104
Pull Down
15161933
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spastic Paraplegia 3a

  • Spg3a

  • Atl1-Hsp

  • Spastic Paraplegia Type 3a

  • Spastic Paraplegia 3

  • Spastic Paraplegia 3, Autosomal Dominant
Adult T-Cell Leukemia/Lymphoma

  • Adult T-Cell Leukemia

  • Atll

  • Adult T-Cell Leukaemia

  • Adult T-Cell Leukaemia/Lymphoma

  • Adult T-Cell Lymphoma

  • T Cell Leukemia Lymphoma Adult

  • Leukemia-Lymphoma, Adult T-Cell

  • Leukemia, T-Cell

  • Adult T-Cell Lymphoma/Leukemia
Spondylolysis

  • Acquired Spondylolysis
Hereditary Sensory And Autonomic Neuropathy Type 1

  • Hereditary Sensory And Autonomic Neuropathy Type I

  • Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

  • Hsan1e

  • Hsan1

  • Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

  • Hsn1e

  • Hsnie

  • Hereditary Sensory Neuropathy Type Ie

  • Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

  • Hereditary Sensory And Autonomic Neuropathy Type Ie

  • Hereditary Sensory And Autonomic Neuropathy Type 1e

  • Hereditary Sensory Neuropathy With Hearing Loss And Dementia

  • Dnmt1-Complex Disorder

  • Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

  • Hsn Ie

  • Hereditary Sensory Autonomic Neuropathy, Type 1

  • Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Hereditary Sensory Neuropathy

  • Hereditary Sensory And Autonomic Neuropathy

  • Hereditary Sensory And Autonomic Neuropathies

  • Familial Dysautonomia, Type Ii

  • Hsan

  • Sensory Neuropathy Hereditary

  • Neuropathy, Sensory And Autonomic, Hereditary

  • Neuropathy, Sensory, Hereditary

  • Sensory Neuropathy, Hereditary

  • Charcot-Marie-Tooth Disease

  • Cmt - [Charcot-Marie-Tooth Disease]
Hereditary Spastic Paraplegia

  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS01158 ATL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19307 Atl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25798 Atl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATL2 VGNC VGNC:26266
Felis catus ATL2 VGNC VGNC:60009
Rattus norvegicus ATL2 RGD RGD:1305125
Mus musculus ATL2 MGD MGI:1929492
Canis familiaris ATL2 VGNC VGNC:38231
Macaca mulatta ATL2 VGNC VGNC:70116
Others ATL2 NCBI