TBX15 - T-box transcription factor 15 Gene

Also Known as TBX14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6913

About TBX15

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:118,883,047-118,989,510 (from NCBI)

This gene has 3 transcripts (splice variants), 233 orthologues, 16 paralogues and is associated with 3 phenotypes. Biased expression in fat (RPKM 11.5), liver (RPKM 10.7) and 4 other tissues.

Summary

This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]

TBX15 Products (2)

mRNA	Protein	Name
NM_001330677.2	NP_001317606.1	T-box transcription factor TBX15 isoform 1
NM_152380.3	NP_689593.2	T-box transcription factor TBX15 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBX15 Protein Structure

T-box

0
100
200
300
400
500
602 a.a.

Protein Preferred Names	Protein Names
T-box transcription factor TBX15	T-box 14

TBX15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TBX15	Q96SF7	VENTX	Homo sapiens	O95231	Y2H Prey Pooling	25416956
Intra	TBX15	Q96SF7	VENTX	Homo sapiens	O95231	Y2H Array	31515488
Intra	TBX15	Q96SF7	POLE2	Homo sapiens	P56282	Validated Y2H	25416956
Intra	TBX15	Q96SF7	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	25416956
Intra	TBX15	Q96SF7	ATXN1	Homo sapiens	P54253	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cousin Syndrome	Pelviscapular Dysplasia Craniofacial Dysmorphism, Hypoplasia Of Scapula And Pelvis, And Short Stature Craniofacial Dysmorphism, Hypoplasia Of Scapula And Pelvis And Short Stature Familial Pelvis-Scapular Dysplasia COUSS
Acromegaloid Facial Appearance Syndrome	Afa Syndrome Thick Lips And Oral Mucosa
Ulnar-Mammary Syndrome	Schinzel Syndrome UMS Pallister Ulnar-Mammary Syndrome Ulnar-Mammary Syndrome Of Pallister
Cleft Palate With Or Without Ankyloglossia, X-Linked	Cleft Palate With Ankyloglossia CPX X-Linked Cleft Palate And Ankyloglossia X-Linked Cleft Palate With Or Without Ankyloglossia X-Linked Cleft Palate X-Linked Cleft Palate With Ankyloglossia Cleft Palate, With/Without Ankyloglossia, X-Linked
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Brachydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14272	TBX15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TBX15	VGNC	VGNC:55686
Felis catus	TBX15	VGNC	VGNC:107673
Macaca mulatta	TBX15	VGNC	VGNC:78268
Mus musculus	TBX15	MGD	MGI:1277234
Rattus norvegicus	TBX15	RGD	RGD:1308094
Canis familiaris	TBX15	VGNC	VGNC:47169
Others	TBX15	NCBI