ACP4 - acid phosphatase 4 Gene

Also Known as ACPT; AI1J

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93650

About ACP4

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,790,415-50,795,219 (from NCBI)

This gene has 1 transcript (splice variant), 159 orthologues, 5 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

Acid phosphatases are Enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate Cancer cell line. This gene exhibits a lower level of expression in testicular Cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

ACP4 Products (1)

mRNA Protein Name
NM_033068.3 NP_149059.1 testicular acid phosphatase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
15219672 GOA
enables receptor tyrosine kinase binding IDA
IDA: Inferred from direct assay
15219672 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of ERBB4 signaling pathway IDA
IDA: Inferred from direct assay
15219672 GOA
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
15219672 GOA
involved in negative regulation of protein processing IMP
IMP: Inferred from mutant phenotype
15219672 GOA
involved in odontogenesis IMP
IMP: Inferred from mutant phenotype
27843125 GOA
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
IDA: Inferred from direct assay
15219672 GOA
involved in regulation of neuronal synaptic plasticity IDA
IDA: Inferred from direct assay
15219672 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACP4 Protein Structure

His_Phos_2

His_Phos_2: Histidine phosphatase superfamily (branch 2) (32 - 337)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

testicular acid phosphatase

  • acid phosphatase, testicular

Related Diseases

Diseases Alias
Amelogenesis Imperfecta, Type Ij

  • AI1J

  • Amelogenesis Imperfecta, Type 1j

  • Amelogenesis Imperfecta Type 1j

  • Amelogenesis Imperfecta 1j
Hypoplastic Amelogenesis Imperfecta

  • Amelogenesis Imperfecta Type 1

  • Amelogenesis Imperfecta, Hypoplastic Type

  • Amelogenesis Imperfecta Local Hypoplastic Form
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Congenital Bile Acid Synthesis Defect

  • 3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency

  • Cba

  • Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency

  • Basd

  • Bile Acid Synthesis Defect, Congenital, 1
Xeroderma Pigmentosum, Complementation Group C

  • Xeroderma Pigmentosum, Group C

  • XPC

  • Xpcc

  • Xeroderma Pigmentosum Iii

  • Xp3

  • Xeroderma Pigmentosum Group C

  • Xp Group C

  • Xp, Group C

  • Xeroderma Pigmentosum, Type 3

  • Xeroderma Pigmentosum Complementation Group C

  • XP-C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00189 ACP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19306 Acp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25797 Acp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ACP4 VGNC VGNC:52175
Macaca mulatta ACP4 VGNC VGNC:69396
Mus musculus ACP4 MGD MGI:3644563
Felis catus ACP4 VGNC VGNC:59526
Canis familiaris ACP4 VGNC VGNC:53522
Rattus norvegicus ACP4 RGD RGD:1308270
Others ACP4 NCBI