MYC-RIBOTAC
Based on 1 publication(s) in Google Scholar
MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).
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- Pureté: 98.17%
- Formule: C55H58N10O11S
- Masse moléculaire:1067.17
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MYC-RIBOTAC
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Activité biologique
MYC-RIBOTAC (0-10 μM; 48 hours) decreases the abundance of MYC mRNA and protein levels in HeLa cells in a dose-dependent and RNase L dependent manner[1].
MYC-RIBOTAC (0-10 μM; 48 hours) has antiproliferative and induce-apoptotic effects in HeLa cells and Namalwa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells and Namalwa cells
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Concentration:0-10 μM
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Incubation Time:48 hours
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Result:Had antiproliferative and induce-apoptotic effects in in HeLa cells.
Induced cell cycle arrest and provoked apoptosis and reduced colony formation by about 50% in Namalwa cells.
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Cell Line:HeLa cells
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Concentration:0-10 μM
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Incubation Time:48 hours
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Result:Decreased the abundance of MYC mRNA in HeLa cells in a dose-dependent and RNase L dependent manner, up to around 50% at a 10 μM dose with a concomitant reduction in MYC protein levels.
Chemical Information
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Appearance Solid
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Masse moléculaire 1067.17
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Formule C55H58N10O11S
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(C(NCCOCCOCCOCCOC4=C(O)C=C(/C=C5SC(NC6=CC=CC=C6)=C(C(OCC)=O)C\5=O)C=C4)=O)=C1)NC7=CC=C(C8=NCCN8)C=C7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
DMSO : 100 mg/mL (93.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9371 mL | 4.6853 mL | 9.3706 mL | 23.4264 mL |
| 5 mM | 0.1874 mL | 0.9371 mL | 1.8741 mL | 4.6853 mL | |
| 10 mM | 0.0937 mL | 0.4685 mL | 0.9371 mL | 2.3426 mL | |
| 15 mM | 0.0625 mL | 0.3124 mL | 0.6247 mL | 1.5618 mL | |
| 20 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL | 1.1713 mL | |
| 25 mM | 0.0375 mL | 0.1874 mL | 0.3748 mL | 0.9371 mL | |
| 30 mM | 0.0312 mL | 0.1562 mL | 0.3124 mL | 0.7809 mL | |
| 40 mM | 0.0234 mL | 0.1171 mL | 0.2343 mL | 0.5857 mL | |
| 50 mM | 0.0187 mL | 0.0937 mL | 0.1874 mL | 0.4685 mL | |
| 60 mM | 0.0156 mL | 0.0781 mL | 0.1562 mL | 0.3904 mL | |
| 80 mM | 0.0117 mL | 0.0586 mL | 0.1171 mL | 0.2928 mL |
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