1. Apoptosis
  2. Apoptosis
  3. DB818

DB818 

Cat. No.: HY-122623
Handling Instructions

DB818 is a potent inhibitor of Homeobox A9 (HOXA9). HOXA9 is a transcription factor regulating haematopoiesis and leukaemia cell proliferation, involving in acute myeloid leukaemia (AML). DB818 inhibits AML cell lines growth, induces apoptosis.

For research use only. We do not sell to patients.

DB818 Chemical Structure

DB818 Chemical Structure

CAS No. : 790241-43-9

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Description

DB818 is a potent inhibitor of Homeobox A9 (HOXA9). HOXA9 is a transcription factor regulating haematopoiesis and leukaemia cell proliferation, involving in acute myeloid leukaemia (AML). DB818 inhibits AML cell lines growth, induces apoptosis[1].

IC50 & Target

Homeobox A9 (HOXA9)[1]

In Vivo

DB818 (12.5 mg/kg, 25 mg/kg; s.c.; once daily for 4 days) completely cures Parasitemia in mice infected with B. microti. at dose of 25 mg/kg, while cures 2/3 mice at 12.5 mg/kg[1].
DB818 results recrudescence occurring on mice around day 20 postinfection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

360.44

Formula

C19H16N6S

CAS No.
SMILES

N=C(C1=CC=C(C2=CC=C(C3=NC4=CC=C(C(N)=N)C=C4N3)S2)C=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DB818
Cat. No.:
HY-122623
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