Gnb4 - guanine nucleotide binding protein (G protein), beta 4 Gene

Also Known as Hg2b; G(beta)4; 6720453A21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14696

Summary

Predicted to enable GTPase activity and signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in myelin sheath. Part of heterotrimeric G-protein complex. Is expressed in several structures, including clavicle; eye; genitourinary system; heart valve; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate F. Orthologous to human GNB4 (G protein subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]

Gnb4 Products (8)

mRNA Protein Name
NM_001348062.2 NP_001334991.1 guanine nucleotide-binding protein subunit beta-4 isoform 1
NM_001348104.2 NP_001335033.1 guanine nucleotide-binding protein subunit beta-4 isoform 1
NM_001348105.2 NP_001335034.1 guanine nucleotide-binding protein subunit beta-4 isoform 2
NM_013531.6 NP_038559.2 guanine nucleotide-binding protein subunit beta-4 isoform 1
NM_001348062.1 NP_001334991.1 guanine nucleotide-binding protein subunit beta-4 isoform 2
NM_001348104.1 NP_001335033.1 guanine nucleotide-binding protein subunit beta-4 isoform 3
NM_001348105.1 NP_001335034.1 guanine nucleotide-binding protein subunit beta-4 isoform 4
NM_013531.5 NP_038559.2 guanine nucleotide-binding protein subunit beta-4 isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
part of heterotrimeric G-protein complex IPI
IPI: Inferred from physical interaction
10570481 MGI
is active in synapse EXP
EXP: Inferred from Experiment
34932372 MGI
is active in synapse IDA
IDA: Inferred from direct assay
34932372 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein subunit beta-4

  • heterotrimeric guanine nucleotide-binding protein 2b

  • transducin beta chain 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05549 GNB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22189 Gnb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28711 Gnb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnb4 NCBI NCBI:59345