P4HA2 - prolyl 4-hydroxylase subunit alpha 2 Gene

Also Known as MYP25; lncRNA-PE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8974

About P4HA2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:132,190,147-132,227,853 (from NCBI)

This gene has 21 transcripts (splice variants), 215 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lung (RPKM 10.5), kidney (RPKM 10.5) and 24 other tissues.

Summary

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in Collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In Collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

P4HA2 Products (9)

mRNA Protein Name
NM_001017974.2 NP_001017974.1 prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001142598.2 NP_001136070.1 prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001142599.2 NP_001136071.1 prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor
NM_001365677.2 NP_001352606.1 prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor
NM_001365678.2 NP_001352607.1 prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001365679.2 NP_001352608.1 prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001365680.2 NP_001352609.1 prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001365681.2 NP_001352610.1 prolyl 4-hydroxylase subunit alpha-2 isoform 3 precursor
NM_004199.3 NP_004190.1 prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables procollagen-proline 4-dioxygenase activity IDA
IDA: Inferred from direct assay
9211872 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P4HA2 Protein Structure

P4Ha_N

P4Ha_N: Prolyl 4-Hydroxylase alpha-subunit, N-terminal region (25 - 157)

2OG-FeII_Oxy

2OG-FeII_Oxy: 2OG-Fe(II) oxygenase superfamily (413 - 519)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

prolyl 4-hydroxylase subunit alpha-2

  • 4-PH alpha 2

P4HA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P4HA2 O15460 KIF7 Homo sapiens Q2M1P5
Anti Tag CoIP
33961781
Intra
P4HA2 O15460 P4HB Homo sapiens P07237
Crosslink
30021884
Intra
P4HA2 O15460 P4HB Homo sapiens P07237
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myopia 25, Autosomal Dominant

  • MYP25
Temporal Arteritis

  • Polymyalgia Rheumatica

  • Giant Cell Arteritis

  • Cranial Arteritis

  • Horton Disease

  • Gca

  • Horton'S Disease

  • Rhizomelic Pseudopolyarthritis

  • Arteritis Cranialis

  • Arteritis Temporalis

  • Horton'S Arteritis

  • Horton'S Giant Cell Arteritis

  • Horton'S Temporal Arteritis

  • Horton'S Syndrome

  • Gca - [Giant Cell Arteritis]

  • Senile Arthritis

  • Polymyalgia Arteritica

  • Pmr - [Polymyalgia Rheumatica]

  • Forestier-Certonciny Syndrome

  • Rheumatic Polymyalgia

  • Polymyalgia
Breast Scirrhous Carcinoma

  • Infiltrating Carcinoma Of Breast With Fibrotic Stroma

  • Scirrhous Carcinoma Of Breast
Refractive Error

  • Refractive Errors
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Osteogenesis Imperfecta, Type Viii

  • Osteogenesis Imperfecta Type 8

  • OI8

  • Osteogenesis Imperfecta Type Viii

  • Oi Type Viii

  • Oi, Type Viii

  • Osteogenesis Imperfecta 8

  • Oi-Viii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121172 1,4-DPCA Inhibitor 99.78% Unkown
HY-N2589 Isosaponarin 99.59% Unkown
HY-RS09943 P4HA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18674 P4ha2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25160 P4ha2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus P4HA2 VGNC VGNC:32536
Felis catus P4HA2 VGNC VGNC:68677
Macaca mulatta P4HA2 VGNC VGNC:75742
Canis familiaris P4HA2 VGNC VGNC:44223
Mus musculus P4HA2 MGD MGI:894286
Rattus norvegicus P4HA2 RGD RGD:1309673
Others P4HA2 NCBI