Gilteritinib-d8
Based on 1 Customer Validation
Gilteritinib-d8 is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2377109-74-3
- Formula: C29H36D8N8O3
- Molecular Weight:560.76
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2377109-74-3
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Unlabeled Cas 1254053-43-4
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Appearance Solid
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Molecular Weight 560.76
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Formula C29H36D8N8O3
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Color White to yellow
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SMILES
NC(C(C(NC1=CC(OC)=C(N2CCC(N3C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C3([2H])[2H])C)CC2)C=C1)=N4)=NC(CC)=C4NC5CCOCC5)=O
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Synonyms
ASP2215-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : 100 mg/mL (178.33 mM; ultrasonic and adjust pH to 2 with HCl)
DMSO : 2 mg/mL (3.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[3]. Mori M, et al. Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Invest New Drugs. 2017 Oct;35(5):556-565. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.7833 mL | 8.9165 mL | 17.8329 mL | 44.5824 mL |
| Ethanol | 5 mM | 0.3567 mL | 1.7833 mL | 3.5666 mL | 8.9165 mL |
| 10 mM | 0.1783 mL | 0.8916 mL | 1.7833 mL | 4.4582 mL | |
| 15 mM | 0.1189 mL | 0.5944 mL | 1.1889 mL | 2.9722 mL | |
| 20 mM | 0.0892 mL | 0.4458 mL | 0.8916 mL | 2.2291 mL | |
| 25 mM | 0.0713 mL | 0.3567 mL | 0.7133 mL | 1.7833 mL | |
| 30 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4861 mL | |
| 40 mM | 0.0446 mL | 0.2229 mL | 0.4458 mL | 1.1146 mL | |
| 50 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8916 mL | |
| 60 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.7430 mL | |
| 80 mM | 0.0223 mL | 0.1115 mL | 0.2229 mL | 0.5573 mL | |
| 100 mM | 0.0178 mL | 0.0892 mL | 0.1783 mL | 0.4458 mL |
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