PROKR1 - prokineticin receptor 1 Gene

Also Known as ZAQ; PKR1; GPR73; PK-R1; GPR73a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10887

About PROKR1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,643,579-68,658,251 (from NCBI)

This gene has 1 transcript (splice variant), 109 orthologues and 33 paralogues. Biased expression in fat (RPKM 1.4), adrenal (RPKM 0.7) and 2 other tissues.

Summary

This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

PROKR1 Products (1)

mRNA Protein Name
NM_138964.4 NP_620414.1 prokineticin receptor 1

PROKR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (79 - 338)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

prokineticin receptor 1

  • G protein-coupled receptor 73

Related Diseases

Diseases Alias
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11196 PROKR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990425 Anti-GPR73/PROKR1 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PROKR1 RGD RGD:708443
Felis catus PROKR1 VGNC VGNC:81157
Macaca mulatta PROKR1 VGNC VGNC:106199
Canis familiaris PROKR1 VGNC VGNC:54534
Mus musculus PROKR1 MGD MGI:1929676
Others PROKR1 NCBI