Ppp1r15b - protein phosphatase 1, regulatory subunit 15B Gene

Also Known as CReP; 1810033K10Rik; C530022L24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108954

Summary

Enables protein Phosphatase regulator activity. Involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation and peptidyl-serine dephosphorylation. Acts upstream of or within ER overload response and response to hydrogen peroxide. Part of protein Phosphatase type 1 complex. Is expressed in compacted morula and inner cell mass. Orthologous to human PPP1R15B (protein Phosphatase 1 regulatory subunit 15B). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r15b Products (1)

mRNA Protein Name
NM_133819.3 NP_598580.1 protein phosphatase 1 regulatory subunit 15B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein phosphatase regulator activity IDA
IDA: Inferred from direct assay
14638860 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ER overload response IDA
IDA: Inferred from direct assay
14638860 MGI
acts upstream of or within ER overload response IMP
IMP: Inferred from mutant phenotype
14638860 MGI
acts upstream of or within response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
14638860 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
14638860 MGI
acts upstream of or within response to oxidative stress IDA
IDA: Inferred from direct assay
14638860 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
14638860 MGI
Cellular Component GO Annotation Evidence References Source
part of protein phosphatase type 1 complex IDA
IDA: Inferred from direct assay
14638860 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 15B

  • constitutive repressor of eIF2alpha phosphorylation

  • protein phosphatase 1, regulatory (inhibitor) subunit 15b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123960 Raphin1 Inhibitor 99.74% Unkown
HY-123960A Raphin1 acetate Inhibitor 99.93% Unkown
HY-18956 (E/Z)-Icerguastat Inhibitor 99.44% Unkown
HY-123960B (E/Z)-Raphin1 Inhibitor / Unkown
HY-18956B (E/Z)-Icerguastat acetate Inhibitor / Unkown
HY-RS10987 PPP1R15B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-18956A (E/Z)-Icerguastat hydrochloride Inhibitor / Unkown
HY-RS19102 Ppp1r15b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25591 Ppp1r15b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp1r15b NCBI NCBI:84919