Cysltr1 - cysteinyl leukotriene receptor 1 Gene

Also Known as Cyslt1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114099

About Cysltr1

Primary_assembly X: 71,663,821-71,690,121 reverse strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 177 orthologues, 14 paralogues and is associated with 25 phenotypes. Biased expression in Lung (RPKM 3.4), Heart (RPKM 23.7) and 9 other tissues.

Summary

Enables Leukotriene Receptor activity. Involved in inflammatory response; positive regulation of angiogenesis; and positive regulation of vasoconstriction. Predicted to be integral component of plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl Leukotriene Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr1 Products (1)

mRNA Protein Name
NM_053641.2 NP_446093.1 cysteinyl leukotriene receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables leukotriene receptor activity IDA
IDA: Inferred from direct assay
12418588 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
17910051 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
21105577 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
17910051 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
16331105 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cysltr1 Protein Structure

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (25 - 52)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (25 - 307)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (59 - 84)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (97 - 127)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (139 - 161)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (187 - 216)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (227 - 257)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (275 - 300)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

cysteinyl leukotriene receptor 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13315A Montelukast Antagonist 99.94% Yes
HY-13315 Montelukast sodium Antagonist 99.84% Yes
HY-13315B Montelukast dicyclohexylamine Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13315S1 Montelukast-d6 sodium Antagonist ≥96.0% Unkown
HY-13315S Montelukast-d6 Antagonist / Unkown
HY-19395 MEN-91507 Antagonist / Unkown
HY-RS03494 CYSLTR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03495 Cysltr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03496 Cysltr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cysltr1 NCBI NCBI:10800