CYSLTR1 - cysteinyl leukotriene receptor 1 Gene

Homo sapiens

Also known as CYSLT1; CYSLTR; CYSLT1R; HMTMF81

Gene ID: 10800 | Gene type: protein coding

About CYSLTR1

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:78,271,468-78,327,611 (from NCBI)

This gene has 3 transcripts (splice variants), 177 orthologues and 16 paralogues. Broad expression in urinary bladder (RPKM 6.1), spleen (RPKM 5.2) and 20 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CYSLTR1 Products(4)

mRNA	Protein	Name
NM_001282186.2	NP_001269115.1	cysteinyl leukotriene receptor 1
NM_001282188.2	NP_001269117.1	cysteinyl leukotriene receptor 1
NM_001282187.2	NP_001269116.1	cysteinyl leukotriene receptor 1
NM_006639.4	NP_006630.1	cysteinyl leukotriene receptor 1

CYSLTR1 Protein Structure

7tm_1

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

cysteinyl leukotriene receptor 1

G-protein coupled receptor HG55	LTD4 receptor
cysteinyl leukotriene D4 receptor

Related Diseases

Diseases

Alias

Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma

Vulvar Keratoacanthoma-Like Carcinoma

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia	Eosinophilic Lung Infiltrate
Weingarten'S Syndrome

Acute Asthma

Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal

Adenoid Hypertrophy

Hypertrophy Of Adenoids	Adenoidal Hypertrophy
Enlarged Adenoids	Enlargement Of Adenoids
Adenoidal Enlargement	Adenoids, Hypertrophy
Hypertrophy Of Adenoids Alone	Adenoid Growth
Hyperplasia Of Adenoids	Hypertrophy Of Pharyngeal Tonsil

Respiratory Allergy

Airway Allergy

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Nasal Cavity Disease

Disorder Of Nasal Cavity

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Acute And Chronic Respiratory Failure	Respiratory Insufficiency/Failure
Chronic Respiratory Disease	Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Intrinsic Asthma

Non-Atopic Asthma

Monocytic Leukemia

Monocytic Leukaemia	Schilling'S Leukaemia
Schilling'S Leukemia	M5b Acute Differentiated Monocytic Leukemia

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Chronic Asthma

Persistent Mild Asthma

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Intermittent Asthma

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Rhinitis

Runny Nose

Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps	Asa Triad
Asthma, Aspirin-Induced, Susceptibility To	Asthma, Aspirin-Induced
Asthma, With Nasal Polyps And Aspirin Intolerance	ANPAI
Aia	Aspirin-Intolerant Asthma
Asthma Aspirin-Induced	Nasal Polyps Asthma And Aspirin Sensitivity
Samter Triad	Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13315	Montelukast sodium	Antagonist	99.52%	Yes
HY-13315A	Montelukast	Antagonist	98.86%	Yes
HY-13315B	Montelukast dicyclohexylamine	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13315S1	Montelukast-d6 sodium	Antagonist	≥96.0%	Unkown
HY-13315S	Montelukast-d6	Antagonist	/	Unkown
HY-RS03494	CYSLTR1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS03495	Cysltr1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03496	Cysltr1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CYSLTR1	VGNC	VGNC:71646
Bos taurus	CYSLTR1	VGNC	VGNC:106703
Canis familiaris	CYSLTR1	VGNC	VGNC:50295
Felis catus	CYSLTR1	VGNC	VGNC:61321
Mus musculus	CYSLTR1	MGD	MGI:1926218
Rattus norvegicus	CYSLTR1	RGD	RGD:619796

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