Thrb - thyroid hormone receptor beta Gene

Also Known as Nr1a2; Thrb1; Thrb2; T3R[b]; T3Rbeta; c-erbAbeta

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21834

Summary

Enables chromatin DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including female mating behavior; regulation of transcription by RNA polymerase II; and retinal cone cell apoptotic process. Located in nucleus. Is expressed in several structures, including brown fat; endocrine gland; liver; sensory organ; and vestibulo-cochlear ganglion. Used to study attention deficit hyperactivity disorder; thyroid gland follicular carcinoma; and thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (Thyroid Hormone Receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Thrb Products (2)

mRNA	Protein	Name
NM_001113417.1	NP_001106888.1	thyroid hormone receptor beta isoform 1
NM_009380.3	NP_033406.1	thyroid hormone receptor beta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	17952069	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22079090	MGI
enables nuclear receptor activity	IMP IMP: Inferred from mutant phenotype	20203194	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9405624	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	9927422	MGI
acts upstream of or within female courtship behavior	IMP IMP: Inferred from mutant phenotype	10769387	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15062575	MGI
acts upstream of or within negative regulation of female receptivity	IMP IMP: Inferred from mutant phenotype	10769387	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7566114	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12407160	MGI
acts upstream of or within regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	9832432	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19052228	MGI
acts upstream of or within retinal cone cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20203194	MGI
acts upstream of retinal cone cell development	IMP IMP: Inferred from mutant phenotype	20203194	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	8673137	MGI
acts upstream of or within type I pneumocyte differentiation	IGI IGI: Inferred from genetic interaction	22001906	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17952069	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
thyroid hormone receptor beta	TR beta c-erbA-2 c-erbA-beta nuclear receptor subfamily 1 group A member 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14501	THRB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20346	Thrb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26855	Thrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Thrb	NCBI	NCBI:7068