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ASTE1 - asteroid homolog 1 Gene

Also Known as HT001

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 28990

About ASTE1

This gene has 8 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 3.6), thyroid (RPKM 3.3) and 25 other tissues.

Summary

Predicted to enable nuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. [provided by Alliance of Genome Resources, Apr 2022]

ASTE1 Products (2)

mRNA	Protein	Name
NM_001288950.2	NP_001275879.1	protein asteroid homolog 1 isoform 1
NM_014065.4	NP_054784.2	protein asteroid homolog 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 3' overhang single-stranded DNA endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	34354233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables single-stranded DNA endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	34354233	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	34354233	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	34354233	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASTE1 Protein Structure

XPG_N

XPG_I_2

0
200
400
600
679 a.a.

Protein Preferred Names	Protein Names
protein asteroid homolog 1

ASTE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ASTE1	Q2TB18	XRCC4	Homo sapiens	Q13426	Validated Y2H	25416956
Intra	ASTE1	Q2TB18	XRCC4	Homo sapiens	Q13426	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Osgood-Schlatter'S Disease	Osgood-Schlatter Disease Juvenile Osteochondrosis Of Tibial Tubercle Osteochondrosis Osteochondritis Of Tibial Tubercle Osteochondrosis Of Proximal Tibia Aseptic Necrosis Of The Tibial Tubercle Osteochondrosis Of The Tibial Tubercle Osteochondritis Juvenilis
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01110	ASTE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASTE1	RGD	RGD:1304643
Canis familiaris	ASTE1	VGNC	VGNC:52864
Felis catus	ASTE1	VGNC	VGNC:59981
Mus musculus	ASTE1	MGD	MGI:1913845
Bos taurus	ASTE1	VGNC	VGNC:26225
Macaca mulatta	ASTE1	VGNC	VGNC:84874
Others	ASTE1	NCBI