Esrra - estrogen related receptor, alpha Gene

Also Known as Errra; ERRalpha

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 293701

About Esrra

Primary_assembly 1: 204,104,101-204,114,268 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 175 orthologues, 8 paralogues and is associated with 15 phenotypes. Biased expression in Heart (RPKM 313.6), Muscle (RPKM 294.8) and 9 other tissues.

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including regulation of osteoblast differentiation; regulation of osteoclast differentiation; and response to estradiol. Located in nucleus. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Esrra Products (1)

mRNA Protein Name
NM_001008511.2 NP_001008511.2 steroid hormone receptor ERR1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20215575 RGD
Biological Process GO Annotation Evidence References Source
involved in cartilage development IMP
IMP: Inferred from mutant phenotype
17170100 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17170100 RGD
involved in positive regulation of cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
20215575 RGD
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11381083 RGD
involved in regulation of ossification IMP
IMP: Inferred from mutant phenotype
12193582 RGD
involved in regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
11381083 RGD
involved in regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
12193582 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15458797 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esrra Protein Structure

NR_DBD_ERR

NR_DBD_ERR: cd07170 (72 - 167)

NR_LBD_ERR

NR_LBD_ERR: cd06946 (195 - 418)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 422 a.a.
Protein Preferred Names Protein Names

steroid hormone receptor ERR1

  • ERR-alpha

  • nuclear receptor subfamily 3 group B member 1

  • orphan nuclear receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04537 ESRRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04538 Esrra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04539 Esrra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esrra NCBI NCBI:2101