Gpsm2 - G-protein signalling modulator 2 (AGS3-like, C. elegans) Gene

Also Known as LGN; Pins; 6230410J09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76123

Summary

Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Acts upstream of or within establishment of mitotic spindle orientation and lung epithelial cell differentiation. Located in apical part of cell and lateral cell cortex. Is expressed in several structures, including gonad; lung; nervous system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Gpsm2 Products (1)

mRNA Protein Name
NM_029522.2 NP_083798.2 G-protein-signaling modulator 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
22952234 MGI
enables GDP-dissociation inhibitor activity IDA
IDA: Inferred from direct assay
22952234 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22117215 MGI
Cellular Component GO Annotation Evidence References Source
located in lateral cell cortex IDA
IDA: Inferred from direct assay
26766442 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G-protein-signaling modulator 2

  • pins homolog (Drosophia)

Gpsm2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Gpsm2 Q8VDU0 NUMA1 Homo sapiens Q14980-2
ITC
23665171
Cross
Gpsm2 Q8VDU0 NUMA1 Homo sapiens Q14980-2
FPS
23665171
Cross
Gpsm2 Q8VDU0 DLG4 Homo sapiens P78352
FPS
22117215
Cross
Gpsm2 Q8VDU0 Dlg1 Rattus norvegicus Q62696
Anti Tag CoIP
22117215
Cross
Gpsm2 Q8VDU0 Dlg1 Rattus norvegicus Q62696
FPS
22117215
Cross
Gpsm2 Q8VDU0 Dlg1 Rattus norvegicus Q62696
Pull Down
22117215
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05760 GPSM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22538 Gpsm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29058 Gpsm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpsm2 NCBI NCBI:29899