LMAN2 - lectin, mannose binding 2 Gene

Also Known as GP36B; VIP36; C5orf8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10960

About LMAN2

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,331,567-177,351,668 (from NCBI)

This gene has 11 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 56.0), testis (RPKM 45.6) and 25 other tissues.

Summary

This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]

LMAN2 Products (1)

mRNA Protein Name
NM_006816.3 NP_006807.1 vesicular integral-membrane protein VIP36 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables D-mannose binding IMP
IMP: Inferred from mutant phenotype
20477988 GOA
enables carbohydrate binding IDA
IDA: Inferred from direct assay
23701871 GOA
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
20477988 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20477988 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
22016386 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
20477988 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
20477988 GOA
located in cell surface IDA
IDA: Inferred from direct assay
22016386 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
15308636 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
22016386 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22016386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMAN2 Protein Structure

Lectin_leg-like

Lectin_leg-like: Legume-like lectin family (53 - 277)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
Protein Preferred Names Protein Names

vesicular integral-membrane protein VIP36

  • epididymis secretory sperm binding protein

Recombinant LMAN2 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P71151 LMAN2 Protein, Human (HEK293, His) Q12907 (D45-R322) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS07704 LMAN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07705 LMAN2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19214 Lman2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20562 Lman2l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25703 Lman2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27071 Lman2l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LMAN2 VGNC VGNC:63246
Canis familiaris LMAN2 VGNC VGNC:42708
Mus musculus LMAN2 MGD MGI:1914140
Rattus norvegicus LMAN2 RGD RGD:1308965
Macaca mulatta LMAN2 VGNC VGNC:74302
Bos taurus LMAN2 VGNC VGNC:30920
Others LMAN2 NCBI