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Tgfbr2 - transforming growth factor, beta receptor II Gene

Also Known as DNIIR; RIIDN; TBR-II; TbetaRII; TbetaR-II; 1110020H15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21813

About Tgfbr2

Chromosome 9: 115,913,361-116,004,428 reverse strand.GRCm39:CM001002.3

This gene has 2 transcripts (splice variants), 263 orthologues, 11 paralogues and is associated with 41 phenotypes. Broad expression in lung adult (RPKM 56.6), subcutaneous fat pad adult (RPKM 56.5) and 23 other tissues.

Summary

Enables SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; and prostate Cancer. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system Cancer (multiple); hereditary nonpolyposis colorectal Cancer type 6; and pancreatic Cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr2 Products (2)

mRNA	Protein	Name
NM_029575.3	NP_083851.3	TGF-beta receptor type-2 isoform 2 precursor
NM_009371.3	NP_033397.3	TGF-beta receptor type-2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SMAD binding	IDA IDA: Inferred from direct assay	12773577	MGI
enables kinase activator activity	IDA IDA: Inferred from direct assay	16806156	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12773577	MGI
enables transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	17878231	MGI
enables transforming growth factor beta receptor activity	IGI IGI: Inferred from genetic interaction	17878231	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Langerhans cell differentiation	IMP IMP: Inferred from mutant phenotype	17938236	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within SMAD protein signal transduction	IDA IDA: Inferred from direct assay	16806156	MGI
involved in atrioventricular valve morphogenesis	IMP IMP: Inferred from mutant phenotype	20652948	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	12975342	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	17078885	MGI
acts upstream of or within bronchus development	IMP IMP: Inferred from mutant phenotype	18990706	MGI
acts upstream of or within bronchus morphogenesis	IMP IMP: Inferred from mutant phenotype	18990706	MGI
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	20652948	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	18498113	MGI
NOT involved in cell proliferation involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	20652948	MGI
involved in embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	12975342	MGI
involved in embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	12975342	MGI
involved in endocardial cushion fusion	IMP IMP: Inferred from mutant phenotype	20652948	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	10030593	MGI
acts upstream of or within growth plate cartilage chondrocyte growth	IMP IMP: Inferred from mutant phenotype	21420963	MGI
acts upstream of or within growth plate cartilage development	IGI IGI: Inferred from genetic interaction	21420963	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16332365	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	17050629	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10030593	MGI
involved in inferior endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	17050629	MGI
acts upstream of or within lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	11641223	MGI
acts upstream of or within lens fiber cell apoptotic process	IDA IDA: Inferred from direct assay	11641223	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	18990706	MGI
acts upstream of or within lung lobe morphogenesis	IMP IMP: Inferred from mutant phenotype	18990706	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	18990706	MGI
acts upstream of or within mammary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15781643	MGI
involved in membranous septum morphogenesis	IMP IMP: Inferred from mutant phenotype	20652948	MGI
involved in miRNA transport	IMP IMP: Inferred from mutant phenotype	25801897	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	17050629	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	20652948	MGI
acts upstream of or within positive regulation of B cell tolerance induction	IMP IMP: Inferred from mutant phenotype	16973387	MGI
acts upstream of or within positive regulation of NK T cell differentiation	IMP IMP: Inferred from mutant phenotype	16973387	MGI
acts upstream of or within positive regulation of T cell tolerance induction	IMP IMP: Inferred from mutant phenotype	16973387	MGI
acts upstream of or within positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	23868260	MGI
acts upstream of or within positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	11641223	MGI
involved in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	17050629	MGI
involved in positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	12975342	MGI
acts upstream of or within positive regulation of tolerance induction to self antigen	IMP IMP: Inferred from mutant phenotype	16973387	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15781643	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21420963	MGI
acts upstream of or within regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	12975342	MGI
involved in response to cholesterol	IDA IDA: Inferred from direct assay	17878231	MGI
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	12975342	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	18990706	MGI
NOT involved in superior endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	17050629	MGI
acts upstream of or within trachea formation	IMP IMP: Inferred from mutant phenotype	18990706	MGI
acts upstream of or within trachea morphogenesis	IMP IMP: Inferred from mutant phenotype	18990706	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21420963	MGI
involved in tricuspid valve morphogenesis	IMP IMP: Inferred from mutant phenotype	20652948	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	12975342	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	17050629	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16973387	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfbr2 Protein Structure

ecTbetaR2

STKc_TGFbR2_like

0
100
200
300
400
500
567 a.a.

Protein Preferred Names	Protein Names
TGF-beta receptor type-2	TGF-beta receptor II TGF-beta receptor type II TGF-beta type II receptor TGFR-2 transforming growth factor-beta receptor type II

Recombinant Tgfbr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7427	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc)	Q62312-2 (I24-D159)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7428	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His)	Q62312-2 (I24-D159)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78801	TGFBR2/TGF-beta RII Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q62312-1 (I24-D184)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100115	TA-02	Inhibitor	99.44%	Unkown
HY-137506	XST-14		99.26%	Unkown
HY-RS14447	TGFBR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14448	Tgfbr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14449	Tgfbr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-137063	(+)-ITD-1		/	Unkown
HY-174530	Human TGFBR2 mRNA		/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99963	Sudubrilimab	Inhibitor	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfbr2	NCBI	NCBI:7048
Rattus norvegicus	Tgfbr2	NCBI	NCBI:81810
Macaca mulatta	Tgfbr2	NCBI	NCBI:703088