3-Hydroxy-2-methylpyridine
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3-Hydroxy-2-methylpyridine is a pharmaceutical intermediate that can be used in the synthesis of pyrimidines. 3-Hydroxy-2-methylpyridine acts as a corrosion inhibitor, serving as a mixed-type corrosion inhibitor for carbon steel in HCl medium.
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- Pureza: 99.65%
- No. CAS: 1121-25-1
- Fòrmula: C6H7NO
- Peso molecular:109.13
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PANC-1 | IC50 |
>100 μM
Compound: 4
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Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay
Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay
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[PMID: 28495081] |
3-Hydroxy-2-methylpyridine (10-5-10-2 M) acts as a mixed-type corrosion inhibitor for carbon steel in 1 M HCl. Its corrosion inhibition efficiency increases with rising concentration (reaching 91.1% at 10-2 M and 303 K, 95.3% at 10-2 M and 313 K, and 95.4% at 10-2 M and 323 K), and shows a slight increase with elevated temperature across all tested concentrations[2].
3-Hydroxy-2-methylpyridine (10-5-10-2 M) reduces the corrosion rate of carbon steel in 1 M HCl in a concentration-dependent manner; the corrosion inhibition efficiency measured by the weight loss method reaches 89.8% at 10-2 M and 303 K, 92.4% at 10-2 M and 313 K, and 94.1% at 10-2 M and 323 K, and the obtained results are highly consistent with those from polarization measurements[2].
The adsorption behavior of 3-Hydroxy-2-methylpyridine (10-5-10-2 M) on carbon steel in a 1 M HCl system shows concentration dependence[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1121-25-1
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Appearance Solid
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Peso molecular 109.13
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Fòrmula C6H7NO
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Color Off-white to light brown
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SMILES
CC1=NC=CC=C1O
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Structure Classification
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
DMSO : 100 mg/mL (916.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (45.82 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (45.82 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (554 KB)
- English - EN (554 KB)
- Français - FR (554 KB)
- Deutsch - DE (554 KB)
- Norwegian - NO (554 KB)
- Español - ES (554 KB)
- Swedish - SV (554 KB)
- Italian - IT (554 KB)
- Korean - KR (554 KB)
- Portuguese - PT (554 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.1634 mL | 45.8169 mL | 91.6338 mL | 229.0846 mL |
| 5 mM | 1.8327 mL | 9.1634 mL | 18.3268 mL | 45.8169 mL | |
| 10 mM | 0.9163 mL | 4.5817 mL | 9.1634 mL | 22.9085 mL | |
| 15 mM | 0.6109 mL | 3.0545 mL | 6.1089 mL | 15.2723 mL | |
| 20 mM | 0.4582 mL | 2.2908 mL | 4.5817 mL | 11.4542 mL | |
| 25 mM | 0.3665 mL | 1.8327 mL | 3.6654 mL | 9.1634 mL | |
| 30 mM | 0.3054 mL | 1.5272 mL | 3.0545 mL | 7.6362 mL | |
| 40 mM | 0.2291 mL | 1.1454 mL | 2.2908 mL | 5.7271 mL | |
| 50 mM | 0.1833 mL | 0.9163 mL | 1.8327 mL | 4.5817 mL | |
| 60 mM | 0.1527 mL | 0.7636 mL | 1.5272 mL | 3.8181 mL | |
| 80 mM | 0.1145 mL | 0.5727 mL | 1.1454 mL | 2.8636 mL | |
| 100 mM | 0.0916 mL | 0.4582 mL | 0.9163 mL | 2.2908 mL |
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