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Referencia número: HY-182460

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Gambogin

Gambogin is an α-glucosidase inhibitor, found in the resin and dry latex of Garcinia hanburyi. Gambogin exists as an inseparable diastereomeric pair of C-2 epimers (8a and 8b), with 8a having an α-glucosidase inhibitory IC₅₀ of 209.2 μM and 8b showing α-glucosidase inhibitory IC₅₀ > 300 μM. Gambogin can be used for the research of type 2 diabetes and cervical cancer.

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No. CAS: 173792-67-1
Fòrmula: C₃₈H₄₆O₆
Peso molecular:598.77

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Gambogin Chemical Structure

No. CAS: 173792-67-1

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

α‑glucosidase

209.2 μM (IC₅₀)

In Vitro

Gambogin (Compound 8) isomer 8a (20 min) modestly inhibits Saccharomyces cerevisiae α-glucosidase with an IC₅₀ of 209.2 μM, while gambogin isomer 8b shows no inhibitory activity at concentrations up to 300 μM^[1].
Gambogin (24 h) potently inhibits the growth of cultured HeLa and HEL #17 cells, with minimum inhibitory concentration values of 6.25 μg/mL and 3.13 μg/mL, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 173792-67-1
Peso molecular 598.77
Fòrmula C₃₈H₄₆O₆
SMILES

O=C1C2=C(O[C@@]3([C@@](C4=O)(C/C=C(C)\C)OC5(C)C)[C@@]5([H])C[C@@]4([H])C=C31)C(C/C=C(C)\C)=C6C(C=CC(CC/C=C(C)/C)(C)O6)=C2O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen Y, et al. Caged polyprenylated xanthones from the resin of Garcinia hanburyi. Fitoterapia. 2016;109:106-112. [Content Brief]

[2]. Asano J, et al. Cytotoxic xanthones from Garcinia hanburyi. Phytochemistry. 1996;41(3):815-820. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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