CDH13 - cadherin 13 Gene

Also Known as CDHH; P105

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1012

About CDH13

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:82,626,969-83,800,640 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 33 paralogues. Broad expression in endometrium (RPKM 22.0), heart (RPKM 17.7) and 16 other tissues.

Summary

This gene encodes a member of the Cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other Cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from Apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

CDH13 Products (6)

mRNA	Protein	Name
NM_001220488.2	NP_001207417.1	cadherin-13 isoform 2
NM_001220489.2	NP_001207418.1	cadherin-13 isoform 3 precursor
NM_001220490.2	NP_001207419.1	cadherin-13 isoform 4
NM_001220491.2	NP_001207420.1	cadherin-13 isoform 5 precursor
NM_001220492.2	NP_001207421.1	cadherin-13 isoform 6 precursor
NM_001257.5	NP_001248.1	cadherin-13 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables cadherin binding	IDA IDA: Inferred from direct assay	10601632	GOA
enables lipoprotein particle binding	IDA IDA: Inferred from direct assay	11027617	GOA
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	16013438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	15703273	GOA
involved in Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	15703273	GOA
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	10601632	GOA
involved in endothelial cell migration	IDA IDA: Inferred from direct assay	14729458	GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	10601632	GOA
involved in keratinocyte proliferation	IDA IDA: Inferred from direct assay	15816843	GOA
involved in lamellipodium assembly	IDA IDA: Inferred from direct assay	15703273	GOA
involved in localization within membrane	IMP IMP: Inferred from mutant phenotype	17573778	GOA
involved in low-density lipoprotein particle mediated signaling	IDA IDA: Inferred from direct assay	16013438	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	14729458	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10737605	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	16013438	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	14729458	GOA
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	17573778	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15364621	GOA
involved in positive regulation of positive chemotaxis	IDA IDA: Inferred from direct assay	16013438	GOA
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15364621	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16099944	GOA
involved in regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	17573778	GOA
involved in regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17573778	GOA
involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	16873731	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in caveola	IDA IDA: Inferred from direct assay	9650591	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10737605	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	16873731	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	10737605	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10737605	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDH13 Protein Structure

Cadherin_pro

Cadherin

0
200
400
600
760 a.a.

Protein Preferred Names	Protein Names
cadherin-13	H-cadherin (heart)

CDH13 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81725	H Cadherin Antibody (YA1470)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Vacterl Association	Vater Association Vater Syndrome
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Polyposis Coli Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Seminoma	Seminoma, Pure
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Scoliosis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS02324	CDH13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17274	Cdh13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23728	Cdh13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDH13	VGNC	VGNC:27093
Mus musculus	CDH13	MGD	MGI:99551
Rattus norvegicus	CDH13	RGD	RGD:619745
Macaca mulatta	CDH13	VGNC	VGNC:70807
Canis familiaris	CDH13	VGNC	VGNC:39022
Others	CDH13	NCBI