Lycorine methiodide
Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC50 values greater than 10 μM.
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- No. CAS: 15069-99-5
- Fòrmula: C17H20INO4
- Peso molecular:429.25
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Almacenamiento:
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| B16-F10 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| Hs 683 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| SK-MEL-28 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| U-373MG ATCC | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
Chemical Information
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No. CAS 15069-99-5
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Peso molecular 429.25
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Fòrmula C17H20INO4
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SMILES
C[N+]12[C@@]3([H])[C@]([C@@H]([C@H](C=C3CC2)O)O)([H])C4=CC(OCO5)=C5C=C4C1.[I-]
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Synonyms
N-Methyllycorine iodide
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Lamoral-Theys D, et al. Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. J Med Chem. 2009 Oct 22;52(20):6244-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lycorine methiodide Related Classifications
HY-137052 Related Classifications
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