15069-99-5
Chemical Structure
Lycorine methiodide
Synonym(s): N-Methyllycorine iodide
- CAS No.: 15069-99-5
- Formula:C17H20INO4
- Molecular Weight:429.25
IUPAC Name: (1S,2S,3a1S,12bS)-1,2-dihydroxy-6-methyl-1,2,3a1,4,5,6,7,12b-octahydro-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium iodide
InChIKey: QWPJQWHIXCZTRG-XUPBFBPUSA-M
SMILES: C[N+]12[C@@]3([H])[C@]([C@@H]([C@H](C=C3CC2)O)O)([H])C4=CC(OCO5)=C5C=C4C1.[I-]
Biological Activity: Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC50 values greater than 10 μM[1].
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Lycorine methiodide | Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC50 values greater than 10 μM. | |||||||||||||||||||||
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- [1]. Lamoral-Theys D, et al. Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. J Med Chem. 2009 Oct 22;52(20):6244-56. [Content Brief]
Keywords
