Lycorine methiodide
Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC50 values greater than 10 μM.
For research use only. We do not sell to patients.
- CAS No.: 15069-99-5
- Formula: C17H20INO4
- Molecular Weight:429.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| B16-F10 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| Hs 683 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| SK-MEL-28 | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
| U-373MG ATCC | IC50 |
>10 μM
Compound: 13, lycorine N-methyl iodide
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Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay
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[PMID: 19788245] |
Chemical Information
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CAS No. 15069-99-5
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Molecular Weight 429.25
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Formula C17H20INO4
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SMILES
C[N+]12[C@@]3([H])[C@]([C@@H]([C@H](C=C3CC2)O)O)([H])C4=CC(OCO5)=C5C=C4C1.[I-]
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Synonyms
N-Methyllycorine iodide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lamoral-Theys D, et al. Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. J Med Chem. 2009 Oct 22;52(20):6244-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lycorine methiodide Related Classifications
HY-137052 Related Classifications
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