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  3. Drug Derivative
  4. Lycorine methiodide

Lycorine methiodide  (Synonyms: N-Methyllycorine iodide)

Cat. No.: HY-137052
Handling Instructions Technical Support

Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC50 values greater than 10 μM.

For research use only. We do not sell to patients.

Lycorine methiodide

Lycorine methiodide Chemical Structure

CAS No. : 15069-99-5

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Lycorine methiodide Related Antibodies

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Description

Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC50 values greater than 10 μM[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
>10 μM
Compound: 13, lycorine N-methyl iodide
Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay
[PMID: 19788245]
B16-F10 IC50
>10 μM
Compound: 13, lycorine N-methyl iodide
Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay
[PMID: 19788245]
Hs 683 IC50
>10 μM
Compound: 13, lycorine N-methyl iodide
Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay
[PMID: 19788245]
SK-MEL-28 IC50
>10 μM
Compound: 13, lycorine N-methyl iodide
Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay
[PMID: 19788245]
U-373MG ATCC IC50
>10 μM
Compound: 13, lycorine N-methyl iodide
Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay
Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay
[PMID: 19788245]
Molecular Weight

429.25

Formula

C17H20INO4
CAS No.
SMILES

C[N+]12[C@@]3([H])[C@]([C@@H]([C@H](C=C3CC2)O)O)([H])C4=CC(OCO5)=C5C=C4C1.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lycorine methiodide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lycorine methiodide15069-99-5N-MethyllycorineDrug DerivativeDrug derivativeA549OE21Hs683U373SKMELB16F10Inhibitorinhibitorinhibit

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