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Referencia número: HY-186246

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TUG-2304

TUG-2304 is a highly selective free fatty acid receptor 2 (FFA2, GPR43) antagonist that completely suppresses propionate-induced neutrophil migration and respiratory burst. TUG-2304 is applicable to research related to metabolic and inflammatory diseases.

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No. CAS: 3034674-48-8
Fòrmula: C₂₀H₂₀F₃N₅O₂
Peso molecular:419.40

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

TUG-2304 Chemical Structure

No. CAS: 3034674-48-8

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

GPR43

Ver todos los productos específicos de isoformas Free Fatty Acid Receptor :

In Vitro

TUG-2304 (compound 16l) (1 nM-10 μM) completely inhibits propionate-induced migration of human neutrophils over the concentration range of 1 nM to 10 μM^[1].
TUG-2304 (100 pM-10 μM) completely inhibits propionate-induced respiratory burst in human neutrophils, with a pIC₅₀ of 8.24 nM, and its activity is specific to FFA2-mediated activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-∞	Bioavailability	T_1/2	V_d	CL_total
Mice^[1]	5 mg/kg	i.v.	/	/	441000 min·ng/mL	/	24 min	400 mL/kg	11 mL/min/kg
Mice^[1]	10 mg/kg	p.o.	30 min	6240 ng/mL	389000 min·ng/mL	44 %	/	/	/

In Vivo

TUG-2304 (compound 16l) (5-10 mg/kg; i.v., p.o.; single dose) exhibits favorable pharmacokinetic properties in male BALB/cAnC mice, with an oral bioavailability of 44%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3034674-48-8
Peso molecular 419.40
Fòrmula C₂₀H₂₀F₃N₅O₂
SMILES

FC(F)(F)C(C=C1)=CC=C1C[C@H](NC(CC2=CC(OC)=CC=C2)=O)CC3=NN=NN3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Valentini A, et al. Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. Journal of medicinal chemistry. 2023 May 11;66(9):6105-6121. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- In Vitro
- In Vivo
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TUG-2304

Ver todos los productos específicos de isoformas Free Fatty Acid Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

TUG-2304 Related Classifications

HY-186246 Related Classifications