Mir221 - microRNA 221 Gene

ADC Targets in Oncology

2026-04-10

Also Known as rno-mir-221

Species: Rattus norvegicus

Gene Type: ncRNA

Gene ID: 100314163

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	32194220	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	19438724	RGD
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	32194220	RGD
involved in positive regulation of Schwann cell migration	IMP IMP: Inferred from mutant phenotype	22393241	RGD
involved in positive regulation of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	22393241	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	29957877	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pre-clinical Phase

Cat. No.	Product Name	Purity	Rare Diseases
HY-R00464	hsa-miR-221-3p mimic	99.23%	Unkown
HY-RI00464	hsa-miR-221-3p inhibitor	99.14%	Unkown
HY-R00465	hsa-miR-221-5p mimic	97.50%	Unkown
HY-RI00465	hsa-miR-221-5p inhibitor	99.55%	Unkown
HY-R00464A	hsa-miR-221-3p agomir	96.87%	Unkown
HY-R02845	mmu-miR-221-5p mimic	93.81%	Unkown
HY-RI00464A	hsa-miR-221-3p antagomir	97.04%	Unkown
HY-RI02845	mmu-miR-221-5p inhibitor	99.53%	Unkown
HY-125026	MyomiRs-IN-1	/	Unkown
HY-R00465A	hsa-miR-221-5p agomir	/	Unkown
HY-R02845A	mmu-miR-221-5p agomir	/	Unkown
HY-R04311	rno-miR-221-5p mimic	/	Unkown
HY-R04311A	rno-miR-221-5p agomir	/	Unkown
HY-RI00465A	hsa-miR-221-5p antagomir	/	Unkown
HY-RI02845A	mmu-miR-221-5p antagomir	/	Unkown
HY-RI04311	rno-miR-221-5p inhibitor	/	Unkown
HY-RI04311A	rno-miR-221-5p antagomir	/	Unkown

Cat. No.

Product Name

Effect