2. Gene
  3. Mir221 - microRNA 221 Gene

Mir221 - microRNA 221 Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rno-mir-221

Gene ID: 100314163 | Gene type: ncRNA

About Mir221

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
32194220 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
19438724 RGD
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
32194220 RGD
involved in positive regulation of Schwann cell migration IMP
IMP: Inferred from mutant phenotype
22393241 RGD
involved in positive regulation of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
22393241 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
29957877 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00464 hsa-miR-221-3p mimic 99.23% Unkown
HY-RI00464 hsa-miR-221-3p inhibitor 99.14% Unkown
HY-R00465 hsa-miR-221-5p mimic 97.50% Unkown
HY-RI00465 hsa-miR-221-5p inhibitor 99.55% Unkown
HY-R02845 mmu-miR-221-5p mimic 93.81% Unkown
HY-RI02845 mmu-miR-221-5p inhibitor 99.53% Unkown
HY-125026 MyomiRs-IN-1 / Unkown
HY-R00464A hsa-miR-221-3p agomir / Unkown
HY-R00465A hsa-miR-221-5p agomir / Unkown
HY-R02845A mmu-miR-221-5p agomir / Unkown
HY-R04311 rno-miR-221-5p mimic / Unkown
HY-R04311A rno-miR-221-5p agomir / Unkown
HY-RI00464A hsa-miR-221-3p antagomir / Unkown
HY-RI00465A hsa-miR-221-5p antagomir / Unkown
HY-RI02845A mmu-miR-221-5p antagomir / Unkown
HY-RI04311 rno-miR-221-5p inhibitor / Unkown
HY-RI04311A rno-miR-221-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir221 NCBI NCBI:407006