2. Gene
  3. Mir126b - microRNA 126b Gene

Mir126b - microRNA 126b Gene

  • Gene
  • Agent
Rattus norvegicus

Also known as Mir126; Mir126a; rno-mir-126; rno-mir-126a

Gene ID: 100314237 | Gene type: ncRNA

About Mir126b

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
31002170 RGD
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
33416109 RGD
involved in positive regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
31964421 RGD
involved in positive regulation of transforming growth factor beta production IDA
IDA: Inferred from direct assay
31002170 RGD
involved in positive regulation of vascular endothelial cell proliferation IDA
IDA: Inferred from direct assay
31002170 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R02650 mmu-miR-126b-3p mimic / Unkown
HY-R02650A mmu-miR-126b-3p agomir / Unkown
HY-R02651 mmu-miR-126b-5p mimic / Unkown
HY-R02651A mmu-miR-126b-5p agomir / Unkown
HY-R04221 rno-miR-126b mimic / Unkown
HY-R04221A rno-miR-126b agomir / Unkown
HY-RI02650 mmu-miR-126b-3p inhibitor / Unkown
HY-RI02650A mmu-miR-126b-3p antagomir / Unkown
HY-RI02651 mmu-miR-126b-5p inhibitor / Unkown
HY-RI02651A mmu-miR-126b-5p antagomir / Unkown
HY-RI04221 rno-miR-126b inhibitor / Unkown
HY-RI04221A rno-miR-126b antagomir / Unkown