CDH11 - cadherin 11 Gene

Also Known as OB; ESWS; CAD11; CDHOB; OSF-4; TBHS2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1009

About CDH11

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:64,943,753-65,123,744 (from NCBI)

This gene has 19 transcripts (splice variants), 223 orthologues, 33 paralogues and is associated with 98 phenotypes. Broad expression in ovary (RPKM 46.8), placenta (RPKM 33.6) and 14 other tissues.

Summary

This gene encodes a type II classical Cadherin from the Cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature Cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. Expression of this particular Cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

CDH11 Products (3)

mRNA Protein Name
NM_001308392.2 NP_001295321.1 cadherin-11 isoform 2 precursor
NM_001330576.2 NP_001317505.1 cadherin-11 isoform 3
NM_001797.4 NP_001788.2 cadherin-11 isoform 1 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
33811546 GOA
involved in focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
33811546 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
33811546 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDH11 Protein Structure

Cadherin

Cadherin: Cadherin domain (64 - 150)

Cadherin

Cadherin: Cadherin domain (164 - 258)

Cadherin

Cadherin: Cadherin domain (273 - 374)

Cadherin

Cadherin: Cadherin domain (391 - 478)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (641 - 788)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
Protein Preferred Names Protein Names

cadherin-11

  • cadherin 11, type 2, OB-cadherin (osteoblast)

CDH11 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84406 CDH11 Antibody (YA4103) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P84406A CDH11 Antibody (YA4103)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Elsahy-Waters Syndrome

  • Brachioskeletogenital Syndrome

  • Bsg Syndrome

  • Branchioskeletogenital Syndrome

  • ESWS

  • Hypospadias, Hypertelorism, Upper Lid Coloboma, And Mixed-Type Hearing Loss

  • Branchio-Skeleto-Genital Syndrome
Teebi Hypertelorism Syndrome 2

  • TBHS2
Exotropia

  • Divergent Concomitant Strabismus

  • Divergent Strabismus

  • Divergent Squint

  • External Strabismus

  • Xt - [Exotropia]
Telangiectatic Osteogenic Sarcoma

  • Telangiectatic Osteosarcoma
Widow'S Peak

  • Widow'S Peak Syndrome

  • Widow'S Peak, Ptosis, And Skeletal Anomalies
Hypertelorism

  • Eyes Wide Apart

  • Eyes Widely Set

  • Hypertelorism Of Orbit

  • Ocular Hypertelorism

  • Orbital Separation Excessive
Ischemic Fasciitis

  • Atypical Decubital Fibroplasia
Dentin Dysplasia

  • Dentinal Dysplasia

  • Dd

  • Dysplasia, Dentin

  • Shell Teeth
Plantar Fascial Fibromatosis

  • Dupuytren'S Contracture Of Foot

  • Ledderhose'S Disease

  • Fibromatosis, Plantar

  • Ledderhose Disease
Unilateral Retinoblastoma
Craniofacial-Deafness-Hand Syndrome

  • CDHS

  • Craniofacial Deafness Hand Syndrome

  • Sommer-Young-Wee-Frye Syndrome

  • Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

  • Craniofacial-Hearing Loss-Hand Syndrome
Intraocular Retinoblastoma

  • Pediatric Intraocular Retinoblastoma
Osteoblastoma
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Osteogenic Sarcoma

  • Osteosarcoma

  • OSRC

  • Osteosarcoma, Somatic

  • Neoplasms, Bone Tissue

  • Bone Tissue Neoplasm

  • Osteoid Sarcoma

  • Skeletal Sarcoma

  • Osteosarcoma Of Bone

  • Bone Sarcoma
Aortic Valve Disease 1

  • Aortic Valve Disease

  • Bicuspid Aortic Valve

  • Aortic Valve Disorder

  • AOVD1

  • Bav

  • Bicuspid Aortic Valve Disease

  • Familial Bicuspid Aortic Valve

  • Aortic Valve Calcification

  • Aovd

  • Aortic Valve, Bicuspid

  • Aortic Valve, Calcification Of

  • Aortic Stenosis, Calcific

  • Familial Bav

  • Calcific Aortic Stenosis

  • Calcification Of Aortic Valve

  • Abnormality Of The Aortic Valve

  • Aortic Valve Disease, Type 1

  • Aortic Valve Disease 2

  • Bicommissural Aortic Valve
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Ptosis

  • Blepharoptosis

  • Drooping Eyelid

  • Droopy Eyelid

  • Ptosis Of Eyelid

  • Paralysis Of Levator Palpebrae Superioris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-177575 CDH11-IN-1 Inhibitor 99.66% Unkown
HY-RS02322 CDH11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19993 Cdh11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26497 Cdh11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDH11 VGNC VGNC:27092
Macaca mulatta CDH11 VGNC VGNC:70805
Rattus norvegicus CDH11 RGD RGD:619742
Canis familiaris CDH11 VGNC VGNC:39020
Mus musculus CDH11 MGD MGI:99217
Others CDH11 NCBI