2. Gene
  3. CDH11 - cadherin 11 Gene

CDH11 - cadherin 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OB; ESWS; CAD11; CDHOB; OSF-4; TBHS2

Gene ID: 1009 | Gene type: protein coding

About CDH11

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:64,943,753-65,123,744 (from NCBI)

This gene has 19 transcripts (splice variants), 223 orthologues, 33 paralogues and is associated with 98 phenotypes. Broad expression in ovary (RPKM 46.8), placenta (RPKM 33.6) and 14 other tissues.

Summary

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

CDH11 Products(3)

mRNA Protein Name
NM_001308392.2 NP_001295321.1 cadherin-11 isoform 2 precursor
NM_001330576.2 NP_001317505.1 cadherin-11 isoform 3
NM_001797.4 NP_001788.2 cadherin-11 isoform 1 preproprotein

CDH11 Protein Structure

Cadherin

Cadherin: Cadherin domain (64 - 150)

Cadherin

Cadherin: Cadherin domain (164 - 258)

Cadherin

Cadherin: Cadherin domain (273 - 374)

Cadherin

Cadherin: Cadherin domain (391 - 478)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (641 - 788)

  • 0
  • 200
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  • 600
  • 796 a.a.
Protein Preferred Names Protein Names

cadherin-11

cadherin 11, type 2, OB-cadherin (osteoblast)

Related Diseases

Diseases Alias
Elsahy-Waters Syndrome

Brachioskeletogenital Syndrome

Bsg Syndrome

Branchioskeletogenital Syndrome

ESWS

Hypospadias, Hypertelorism, Upper Lid Coloboma, And Mixed-Type Hearing Loss

Branchio-Skeleto-Genital Syndrome
Teebi Hypertelorism Syndrome 2

TBHS2
Exotropia

Divergent Concomitant Strabismus

Divergent Strabismus

Divergent Squint

External Strabismus

Xt - [Exotropia]
Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma
Widow'S Peak

Widow'S Peak Syndrome

Widow'S Peak, Ptosis, And Skeletal Anomalies
Hypertelorism

Eyes Wide Apart

Eyes Widely Set

Hypertelorism Of Orbit

Ocular Hypertelorism

Orbital Separation Excessive
Ischemic Fasciitis

Atypical Decubital Fibroplasia
Dentin Dysplasia

Dentinal Dysplasia

Dd

Dysplasia, Dentin

Shell Teeth
Plantar Fascial Fibromatosis

Dupuytren'S Contracture Of Foot

Ledderhose'S Disease

Fibromatosis, Plantar

Ledderhose Disease
Unilateral Retinoblastoma
Craniofacial-Deafness-Hand Syndrome

CDHS

Craniofacial Deafness Hand Syndrome

Sommer-Young-Wee-Frye Syndrome

Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

Craniofacial-Hearing Loss-Hand Syndrome
Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma
Osteoblastoma
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma
Aortic Valve Disease 1

Aortic Valve Disease

Bicuspid Aortic Valve

Aortic Valve Disorder

AOVD1

Bav

Bicuspid Aortic Valve Disease

Familial Bicuspid Aortic Valve

Aortic Valve Calcification

Aovd

Aortic Valve, Bicuspid

Aortic Valve, Calcification Of

Aortic Stenosis, Calcific

Familial Bav

Calcific Aortic Stenosis

Calcification Of Aortic Valve

Abnormality Of The Aortic Valve

Aortic Valve Disease, Type 1

Aortic Valve Disease 2

Bicommissural Aortic Valve
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02322 CDH11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDH11 VGNC VGNC:27092
Macaca mulatta CDH11 VGNC VGNC:70805
Rattus norvegicus CDH11 RGD RGD:619742
Canis familiaris CDH11 VGNC VGNC:39020
Mus musculus CDH11 MGD MGI:99217
Others CDH11 NCBI