2. Gene
  3. Plekha1 - pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Gene

Plekha1 - pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TAPP1; C920009D07Rik

Gene ID: 101476 | Gene type: protein coding

About Plekha1

Summary

Predicted to enable PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Acts upstream of or within several processes, including cellular hormone metabolic process; face morphogenesis; and gonad development. Predicted to be located in cytosol; nucleoplasm; and ruffle membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including ganglia; lung; metanephros; nasal epithelium; and ureter. Orthologous to human PLEKHA1 (pleckstrin homology domain containing A1). [provided by Alliance of Genome Resources, Apr 2022]

Plekha1 Products(10)

mRNA Protein Name
NM_001346515.1 NP_001333444.1 pleckstrin homology domain-containing family A member 1 isoform 2
NM_001357696.1 NP_001344625.1 pleckstrin homology domain-containing family A member 1 isoform 3
NM_001382373.1 NP_001369302.1 pleckstrin homology domain-containing family A member 1 isoform 4
NM_001382374.1 NP_001369303.1 pleckstrin homology domain-containing family A member 1 isoform 2
NM_001382375.1 NP_001369304.1 pleckstrin homology domain-containing family A member 1 isoform 5
NM_001382376.1 NP_001369305.1 pleckstrin homology domain-containing family A member 1 isoform 6
NM_001382377.1 NP_001369306.1 pleckstrin homology domain-containing family A member 1 isoform 7
NM_001382378.1 NP_001369307.1 pleckstrin homology domain-containing family A member 1 isoform 5
NM_001382379.1 NP_001369308.1 pleckstrin homology domain-containing family A member 1 isoform 7
NM_133942.3 NP_598703.1 pleckstrin homology domain-containing family A member 1 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within androgen metabolic process IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within estrogen metabolic process IGI
IGI: Inferred from genetic interaction
19056881 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within female gonad development IGI
IGI: Inferred from genetic interaction
19056881 MGI
acts upstream of or within luteinization IGI
IGI: Inferred from genetic interaction
19056881 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
19056881 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family A member 1

PH domain-containing family A member 1

TAPP-1

tandem PH domain-containing protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10679 PLEKHA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plekha1 NCBI NCBI:59338